Evidence map›Paper›PMID 41521165›Full record

ArticleActa physiologica (Oxford, England)2026

Acyl-CoA Binding Protein in White and Brown Adipose Tissue Is Dispensable for Systemic Energy Metabolism in Mice.

M F Nørremark, R Petersen, P M M Ruppert, E S Jul, T K Doktor, R Nielsen, J F Kappel, S Larsen, J W Kornfeld, S Mandrup and 4 more

Abstract read
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In one paragraph

Article in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

M F NørremarkDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
R PetersenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
P M M RuppertDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
E S JulDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
T K DoktorDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
R NielsenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
J F KappelDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
S LarsenXlab, Center of Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-5170-4337
J W KornfeldDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0002-6802-4442
S MandrupDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
B S AndresenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0001-7488-3035
J HavelundDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
D NeessDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
N J FærgemanDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0002-9281-5287

Funding

Danmarks Frie Forskningsfond 2032-00062BLEO Fondet LF-OC-22-001107Novo Nordisk Fonden NNF20OC0061575UniversityNovo Nordisk Fonden NNF20OC0064744
6 · The paper itself

Abstract

aimAcyl-CoA binding protein plays a vital role in lipid metabolism by mediating the intracellular flux and utilization of long-chain acyl-CoAs. We generated an adipocyte-wide ACBP knockout mouse and a brown adipose tissue-specific ACBP knockout mouse to investigate ACBP function in adipose tissue.

methodsMale mice with conditional targeting of the Acbp gene in adipose tissue (Adipoq-Acbp

resultsWe demonstrate that loss of ACBP in adipose tissue does not affect body weight, fat and lean mass, food intake and systemic energy expenditure, even under cold stress. Global gene expression analysis shows only minor changes in gene expression, whereas lipidomic profiling reveals a subtle increase in acyl-carnitine levels in brown adipose tissue. Lipolytic activity in white adipose tissue as well as plasma glycerol, nonesterified fatty acid and triacylglycerol levels remained unaffected. In addition, no changes in mitochondrial respiration in BAT were observed.

conclusionOur findings suggest that ACBP is dispensable for adipose tissue function and systemic energy metabolism.

Indexed as

Adipose Tissue, BrownAdipose Tissue, WhiteDiazepam Binding InhibitorEnergy MetabolismAnimalsLipid MetabolismMaleMiceMice, KnockoutDiazepam Binding InhibitorACBPacyl‐CoAadipose tissueenergy expenditurefatty acids

Identifiers

PMID41521165
PMCPMC12791089

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.