Evidence map›Paper›PMID 41520338›Full record

ArticleCell reports2026

Sequential RNA polymerase II activation drives human hematopoiesis.

Derek H Janssens, Christine A Codomo, Dominik J Otto, Lev Silberstein, Kami Ahmad, Steve Henikoff

Abstract read
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Derek H JanssensDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA. Electronic address: derek.janssens@vai.org.
Christine A CodomoBasic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Dominik J OttoBasic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA; Translational Data Science IRC, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Lev SilbersteinTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Kami AhmadBasic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Steve HenikoffBasic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.

Funding

Epigenomic profiling of complex tissues with single-cell CUT&RUNR01HG010492 · NHGRI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HENIKOFF, STEVEN · 2019 to 2023
$3.5M
Oncoprotein-regulated lineage plasticity in acute leukemiaK22CA272912 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI Derek Henry Janssens · 2024 to 2026
$577k
Howard Hughes Medical InstituteNCI NIH HHS K22 CA272912NHGRI NIH HHS R01 HG010492
6 · The paper itself

Abstract

Promoter-proximal pausing of RNA polymerase II (Pol II) primes genes for rapid activation, yet how Pol II dynamics are temporally organized in adult stem cells to enable fast and flexible responses to environmental cues remain unknown. To address this, we developed sciCUT&Tag2in1 for joint profiling of Pol II and histone modifications in single cells. By profiling over 200,000 CD34

Indexed as

HematopoiesisRNA Polymerase IICell LineageGranulocyte Colony-Stimulating FactorHematopoietic Stem CellsHistonesHumansPolycomb-Group ProteinsGranulocyte Colony-Stimulating FactorHistonesPolycomb-Group ProteinsRNA Polymerase IICP: molecular biologyCP: stem cell researchCUT&TagG-CSF responsehematopoietic stem cellsinflammatory memorylineage commitmentpolycomb repressionRNA polymerase IIsciCUT&Tag2in1single-cell genomicstranscriptional pausing

Identifiers

PMID41520338
PMCPMC13067999

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.