Evidence map›Paper›PMID 41520312›Full record

ArticleArchives of virology2026

Phage-cocktail-based biocontrol of multidrug-resistant Klebsiella pneumoniae both in vitro and in vivo.

Ling Zou, Yang Yu, Dongxue Yue, Chuanxu Wang, Shijie Xu, Wenhua Liu, Shouzhen Xu, Jing Ma, Hong-Bo Ni, Tao He and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ling Zou *Veterinary Pathogen Biocontrol Laboratory, College of Veterinary Medicine, Qingdao Agricultural University, 266109, Qingdao, PR China.
Yang Yu *Veterinary Pathogen Biocontrol Laboratory, College of Veterinary Medicine, Qingdao Agricultural University, 266109, Qingdao, PR China.
Dongxue YueVeterinary Pathogen Biocontrol Laboratory, College of Veterinary Medicine, Qingdao Agricultural University, 266109, Qingdao, PR China.
Chuanxu WangVeterinary Pathogen Biocontrol Laboratory, College of Veterinary Medicine, Qingdao Agricultural University, 266109, Qingdao, PR China.
Shijie XuVeterinary Pathogen Biocontrol Laboratory, College of Veterinary Medicine, Qingdao Agricultural University, 266109, Qingdao, PR China.
Wenhua LiuVeterinary Pathogen Biocontrol Laboratory, College of Veterinary Medicine, Qingdao Agricultural University, 266109, Qingdao, PR China.
Shouzhen XuVeterinary Pathogen Biocontrol Laboratory, College of Veterinary Medicine, Qingdao Agricultural University, 266109, Qingdao, PR China.
Jing MaVeterinary Pathogen Biocontrol Laboratory, College of Veterinary Medicine, Qingdao Agricultural University, 266109, Qingdao, PR China.
Hong-Bo NiVeterinary Pathogen Biocontrol Laboratory, College of Veterinary Medicine, Qingdao Agricultural University, 266109, Qingdao, PR China.
Tao HeJiangsu Key Laboratory for Food Quality and Safety, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Ran WangJiangsu Key Laboratory for Food Quality and Safety, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Yehui SunVeterinary Pathogen Biocontrol Laboratory, College of Veterinary Medicine, Qingdao Agricultural University, 266109, Qingdao, PR China.
Can ZhangVeterinary Pathogen Biocontrol Laboratory, College of Veterinary Medicine, Qingdao Agricultural University, 266109, Qingdao, PR China. cleverflame@163.com.ORCID http://orcid.org/0000-0002-8367-0709

Funding

Modern Agricultural Technology Industry System of Shandong province SDAIT-27-04the Innovation Program of Qingdao Agricultural University QNDC20250297the National Key R&D Program of China 2023YFD1800303
6 · The paper itself

Abstract

Multidrug-resistant Klebsiella pneumoniae requires alternative therapies. In this study, we characterized two novel phages, PKP K9 (a siphovirus) and PKP Kh11 (a myovirus). Both showed genomic safety and exhibited excellent reproduction and physicochemical tolerance. A cocktail containing both phages had a broad combined host range (85.7%, 72/84) and showed potent in vitro activity with distinct dose-dependent inhibition modes. In a Galleria mellonella infection model, each phage individually and the two combined provided complete prophylactic and therapeutic protection against lethal challenge. The PKP K9/PKP Kh11 cocktail demonstrates significant therapeutic potential against multidrug-resistant K. pneumoniae.

Indexed as

BacteriophagesDrug Resistance, Multiple, BacterialKlebsiella InfectionsKlebsiella pneumoniaeMyoviridaeAnimalsHost SpecificityMothsSiphoviridaeantibacterial activityBacteriophage cocktailbiocontrolGalleria mellonellaKlebsiella pneumoniae

Identifiers

PMID41520312

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.