ArticleScientific reports2026
Comparative evaluation of the biocompatibility and antibacterial efficacy of various toothpaste formulations.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Evaluation of enamel wear after the use of whitening toothpastes.Clinical oral investigations · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to evaluate the biocompatibility of twelve toothpaste formulations using human gingival fibroblast (hGF) cell cultures, and to compare their antibacterial efficacy. In accordance with ethical guidelines, healthy hGF were obtained from individuals. The toothpaste formulations tested included Colgate Total 12 (TP1), Colgate Maximum Cavity Protection (TP2), Curaprox Enzycal (TP3), Elmex Kinder (TP4), Klorhex (TP5), ROCS Baby (TP6), ROCS Kids (TP7), Meridol (TP8), Oral-B Pro Expert Stages (TP9), Sensodyne Pronamel for Kids (TP10), Sensodyne Multi Protection (TP11), and Aquafresh Little Teeth (TP12). The cytotoxic effects of these formulations were evaluated in real-time using the xCELLigence system, which monitored cellular activity at 5-minute intervals over a 72-hour period. The apoptotic effects of the toothpastes at their IC
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