Evidence map›Paper›PMID 41519914›Full record

ArticleNature communications2026

The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion.

Typhanie Dumontet, Kaitlin J Basham, Micah C Foster, Emma Silverman, Kyle A Heard, Dominque Johnson, Chaelin Lee, Samuel W Plaska, David T Breault, David Penton and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Typhanie DumontetTraining Program in Organogenesis, Center for Cell Plasticity and Organ Design, University of Michigan, Ann Arbor, MI, USA. tdumonte@med.umich.edu.ORCID http://orcid.org/0000-0002-1328-9515
Kaitlin J BashamDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.
Micah C FosterDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0009-0002-3139-1502
Emma SilvermanDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.
Kyle A HeardDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.
Dominque JohnsonDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.
Chaelin LeeDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.
Samuel W PlaskaDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
David T BreaultDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0402-4857
David PentonElectrophysiology Facility, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-6425-3766
Felix BeuschleinDepartment of Endocrinology, Diabetology and Clinical Nutrition, University Hospital of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland.ORCID http://orcid.org/0000-0001-7826-3984
Adina F TurcuDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.
Christopher R LaPenseeDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.
Antonio Marcondes LerarioDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8336-6432
Gary D HammerDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-6843-3628

Funding

Mechanisms of Adrenal DifferentiationR01DK062027 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARY D. HAMMER · 2004 to 2026
$8.0M
MECHANISMS LEADING TO ADRENAL ZONATIONR01DK043140 · NIDDK · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI William E Rainey · 1999 to 2026
$7.2M
Michigan Medical Scientist Training Program 2025-2030T32GM156550 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kathleen L. Collins · 2025 to 2026
$3.2M
NIDDK NIH HHS R01 DK043140NIDDK NIH HHS R01 DK062027NIGMS NIH HHS T32 GM156550
6 · The paper itself

Abstract

Glucocorticoid-producing cells of the adrenal cortex (i.e. zona fasciculata, zF) constitute the critical effectors of the hypothalamic-pituitary-adrenal axis, mediating the mammalian stress response. With glucocorticoids being essential for life, zF dysfunction perturbs multiple organs that participate in optimizing cardiometabolic fitness. The zF forms a dynamic and heterogenous cell population endowed with the capacity to remodel through the engagement of both proliferative and differentiation programs that enable the adrenal to adapt and respond to diverse stressors. However, the mechanisms that sustain such differential responsiveness remain poorly understood. In this study, we resolve the transcriptome of the steroidogenic lineage by scRNA-seq using Sf1-Cre

Indexed as

Adrenal GlandsAndrogensGlucocorticoidsHomeodomain ProteinsLipid MetabolismTranscription FactorsAnimalsFemaleMaleMiceMice, KnockoutReceptors, AndrogenSex CharacteristicsZona FasciculataAndrogensGlucocorticoidsHomeodomain ProteinsReceptors, AndrogenTranscription Factors

Identifiers

PMID41519914
PMCPMC12891536

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.