Evidence map›Paper›PMID 41519820›Full record

ArticleNPJ science of food2026

Exploring the role of food-source microRNAs as potential nutritional bioactives in humans.

Christine Leroux, J Bruce German, David A Mills, Dragan Milenkovic

Abstract read
In one paragraph

Article in NPJ science of food, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christine LerouxINRAE, Université Clermont Auvergne, Vetagro Sup, UMRH, Saint-Genès-Champanelle, France.
J Bruce GermanDepartment of Food Science and Technology, University of California Davis, Davis, CA, USA.
David A MillsDepartment of Food Science and Technology, University of California Davis, Davis, CA, USA.
Dragan MilenkovicPlants for Human Health Institute, Department of Food Bioprocessing & Nutrition Sciences, NC State University, Kannapolis, NC, USA. dmilenk@ncsu.edu.

Funding

National Institute of Food and Agriculture Hatch project 7010153
6 · The paper itself

Abstract

MicroRNAs (miRNAs), small noncoding RNAs that regulate gene expression, are mediators of intercellular and cross-kingdom communication. They are detected in foods, and studies argue for their uptake by intestinal cells. To investigate the cumulative influence of food-derived miRNAs on human health, we performed a bioinformatic analysis of miRNomes of eight commonly consumed foods: four fruits (apple, banana, grape, orange) and four animal products (beef, chicken, pork, milk). We identified 2 and 4 common miRNAs among the 20 most abundant in fruits and animal foods, respectively. Functional predictions revealed that miRNAs are likely involved in regulating cell adhesion, cellular organization, or metabolism. Several miRNAs were shown, in the literature, when overexpressed, to exert beneficial effects on physiological functions and to contribute to disease prevention. This study suggests that food-derived miRNAs may act as novel dietary bioactives contributing to the health-promoting properties of whole foods, and when these foods are consumed in combinations.

Identifiers

PMID41519820
PMCPMC12891657

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.