Evidence map›Paper›PMID 41519759›Full record

Trial reportBMC medicine2026

Impact of an eight-week isocaloric vegan dietary intervention on hemogram parameters and lymphocyte subsets: a randomized-controlled trial.

Julian Herter, Frieda Stübing, Volker Lüth, Ann-Kathrin Lederer, Ulrich Salzer, Ana Cecilia Venhoff, Bettina Sehnert, Luciana Hannibal, Reinhard Edmund Voll, Roman Huber and 1 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julian HerterDepartment of Internal Medicine II, Centre for Complementary Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79106, Germany.
Frieda StübingDepartment of Internal Medicine II, Centre for Complementary Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79106, Germany.
Volker LüthDepartment of Internal Medicine II, Centre for Complementary Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79106, Germany.
Ann-Kathrin LedererDepartment of Internal Medicine II, Centre for Complementary Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79106, Germany.
Ulrich SalzerDepartment of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Ana Cecilia VenhoffDepartment of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Bettina SehnertDepartment of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Luciana HannibalLaboratory of Clinical Biochemistry and Metabolism, Department of General Pediatrics, Adolescent Medicine and Neonatology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, 79106, Germany.
Reinhard Edmund VollDepartment of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Roman HuberDepartment of Internal Medicine II, Centre for Complementary Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79106, Germany.
Maximilian Andreas StorzDepartment of Internal Medicine II, Centre for Complementary Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79106, Germany. maximilian.storz@uniklinik-freiburg.de.ORCID 0000-0003-3277-0301

Funding

KVC Habilitationsstipendium 127/2022
6 · The paper itself

Abstract

backgroundWhole food plant-based diets exert anti-inflammatory properties and have been associated with clinical improvements in patients with autoimmune disorders. The underlying mechanisms remain poorly understood and functional insights into nutrient-host physiology cross-talks are urgently warranted. The present study investigated the effects of an isocaloric 8-week vegan diet (VD) intervention on whole blood count parameters and lymphoid composition in comparison to a meat-rich diet (MD).

methodsWe conducted a two-arm, monocentric randomized-controlled trial with healthy adults who were randomly allocated to either a MD or a VD for 8 consecutive weeks. Foods of animal origin were not permitted on the VD, whereas participants in the MD group were asked to consume at least 150 g of meat per day.

resultsFifty-seven participants completed the study. At week 8, significant between-group differences were found for the white blood cell count (median (interquartile range): 5.17 (1.62) *10

conclusionsThe present study suggests that a VD, in comparison to a MD, reduces the number of various immune cells even in healthy individuals. A VD may thus exert anti-inflammatory properties.

trial registrationRegistered at Deutsches Register Klinischer Studien: DRKS00031541.

Indexed as

Diet, VeganLymphocyte SubsetsAdultFemaleHumansLymphocyte CountMaleMiddle AgedCell proliferationClinical trialDietImmune systemImmunophenotypingInflammationNutritionVegan

Identifiers

PMID41519759
PMCPMC12849501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.