Trial reportBMC anesthesiology2026
Different local anesthetic volumes for unilateral spinal anesthesia in varicose vein surgery prospective randomized clinical trial.
Trial report in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06527430 (Different Local Anesthetic Volumes for Unilateral Spinal Anesthesia in Varicose Vein Surgery), which is not on this map. Not yet cited in PubMed.
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Different Local Anesthetic Volumes for Unilateral Spinal Anesthesia in Varicose Vein Surgery
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVaricose vein surgery is one of the most frequent indications for ambulatory vascular interventions. Although spinal anesthesia provides reliable surgical conditions, conventional intrathecal doses may delay mobilization and discharge due to prolonged block duration and hemodynamic instability. Unilateral spinal anesthesia with reduced local anesthetic doses has been proposed to facilitate early recovery. This study aimed to compare the perioperative block characteristics and recovery profiles of two different intrathecal bupivacaine doses in patients undergoing ambulatory varicose vein surgery.
methodsIn this prospective, randomized, double-blind trial, 80 adult patients scheduled for elective varicose vein surgery were allocated to receive either 4 mg (Group I) or 6 mg (Group II) of intrathecal hyperbaric bupivacaine. The primary endpoint was hospital discharge time. Secondary outcomes included the time from initiation to surgery, motor block positivity, motor block regression time, sensory block regression time, mobilization time, and advers effects.
resultsSeventy-four patients completed the study (Group I, n = 36; Group II, n = 38). Baseline demographic and clinical characteristics were comparable between groups. Median discharge time was significantly shorter in Group I compared with Group II (149 vs. 175.5 min, p = 0.002). Similarly, sensory regression time (115 vs. 145.5 min, p = 0.001) and mobilization time (132 vs. 157.5 min, p = 0.001) were shorter in Group I. Motor block regression did not differ significantly between groups (p = 0.172). Higher thoracic sensory block levels were more frequent in Group II (p = 0.03). Hemodynamic parameters were comparable between the groups, except at the first postoperative hour, when heart rate was significantly lower in Group II (p = 0.001).
conclusionsUnilateral spinal anesthesia with 4 mg of hyperbaric bupivacaine provided effective surgical anesthesia for varicose vein surgery while significantly reducing discharge and mobilization times compared with 6 mg. These findings support the use of lower intrathecal doses to enhance recovery and efficiency in ambulatory venous surgery.
trial registrationClinicalTrials.gov, NCT06527430 (Registered on 25 July 2024).
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