Evidence map›Paper›PMID 41519381›Full record

ArticleMucosal immunology2026

Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma.

Rod A Rahimi, Neal P Smith, Amandine Selle, Roya Best, Sidney Martin, Elizabeth Tuttle, Wamia Said, Nandini Samanta, Morris F Ling, Benjamin D Medoff and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Rod A RahimiDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston MA 02129, USA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston MA 02129, USA; Harvard Medical School, Boston, MA, USA. Electronic address: rrahimi@mgh.harvard.edu.
Neal P SmithCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Amandine SelleCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston MA 02129, USA; Harvard Medical School, Boston, MA, USA; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston MA 02129, USA.
Roya BestCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Sidney MartinCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Elizabeth TuttleCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Wamia SaidCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Nandini SamantaCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Morris F LingCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston MA 02129, USA; Harvard Medical School, Boston, MA, USA; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston MA 02129, USA.
Benjamin D MedoffDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston MA 02129, USA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston MA 02129, USA; Harvard Medical School, Boston, MA, USA.
Alexanda-Chloé VillaniCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston MA 02129, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Andrew D LusterCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston MA 02129, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston MA 02129, USA. Electronic address: aluster@mgh.harvard.edu.

Funding

Lung-Resident Memory Th2 cells in Asthma - New Therapeutic TargetsR01AI040618 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LUSTER, ANDREW D · 1997 to 2022
$5.6M
Allergen-specific lung-resident Tregs in asthma: Targetable suppressors of resident memory Th2 cellsR01AI168131 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ANDREW D LUSTER · 2022 to 2026
$3.0M
Deciphering the Achilles Heel of Cancer ImmunotherapyDP2CA247831 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI VILLANI, ALEXANDRA-CHLOE · 2019 to 2019
$2.5M
Lipid shuttling in memory Th2 cell fate and function in allergic asthmaR21AI173732 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHIMI, ROD AMIR · 2023 to 2024
$462k
Defining the development of tissue-resident memory Th2 cells in allergic asthmaR03HL164370 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI RAHIMI, ROD AMIR · 2022 to 2023
$168k
NCI NIH HHS DP2 CA247831NHLBI NIH HHS R03 HL164370NIAID NIH HHS R01 AI040618NIAID NIH HHS R01 AI168131NIAID NIH HHS R21 AI173732
6 · The paper itself

Abstract

T cells play a central role in host protection against respiratory pathogens, but a maladaptive T cell response can lead to pulmonary diseases. Previous studies have examined T cells from the lungs captured via bronchoalveolar lavage (BAL), endobronchial brushings, or biopsies. However, whether these different approaches are capturing distinct T cell phenotypes and/or clonotypes remains unclear. Here, using single cell RNA- and T cell receptor (TCR)-sequencing, we report unique phenotypes and clonotypes of T cells isolated via BAL versus endobronchial brushings in healthy controls (HCs) and allergic asthmatics (AAs). The most significant difference in T cell subset abundance between AAs and HCs was the enrichment of CD4 T helper type 2 (T

Indexed as

AsthmaBronchoalveolar Lavage FluidRespiratory MucosaTh2 CellsT-Lymphocyte SubsetsAdultFemaleHumansImmunologic MemoryImmunophenotypingMaleMemory T CellsMiddle AgedPhenotypeReceptors, Antigen, T-CellReceptors, Antigen, T-CellAsthmaT cellsTranscriptomics

Identifiers

PMID41519381
PMCPMC12983186

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.