Evidence map›Paper›PMID 41519127›Full record

ArticleCell genomics2026

Semantic design: Programming functional genes from genomic context.

Yulin Huang, Ping Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yulin HuangBiological Science Research Center, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Chongqing Technology Innovation Center of Breeding, Academy for Advanced Interdisciplinary Studies, Southwest University, Chongqing 400715, China.
Ping LinBiological Science Research Center, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Chongqing Technology Innovation Center of Breeding, Academy for Advanced Interdisciplinary Studies, Southwest University, Chongqing 400715, China. Electronic address: linpingswu@swu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Generative genomic models hold immense potential for creating intricate biological systems, yet designing precise functional sequences remains challenging. Merchant et al. in Nature present semantic design, which employs the Evo genomic language model to generate novel functional genes based solely on genomic context. Moreover, SynGenome database houses over 120 billion sequences generated through semantic design, spanning a diverse range of functions.

Indexed as

GenomeGenomicsModels, GeneticSemanticsAnimalsDatabases, GeneticHumans

Identifiers

PMID41519127
PMCPMC12903390

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.