Evidence map›Paper›PMID 41518657›Full record

ArticleChemistry & biodiversity2026

Quinolinone and Amicoumacin Derivatives From the Deep Sea-Derived Bacillus rugosus SCSIO 41395 and Their Bacteriostatic Activities Against Pseudomonas aeruginosa.

Yuan Yuan, Tianyuan Jia, Peiyi Lu, Qi Zeng, Yiwei Hu, Kai Zhao, Wanying Zhang, Yue Song, Yonghong Liu, Qingchao Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuan YuanGuangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, State Key Laboratory of Tropical Oceanography, Chinese Academy of Sciences, Guangzhou, China.
Tianyuan JiaShenzhen Third People's Hospital, National Clinical Research Centre for Infectious Disease, The Second Affiliated Hospital of Southern.
Peiyi LuSchool of Medicine, Southern University of Science and Technology, Shenzhen, China.
Qi ZengSchool of Medicine, Southern University of Science and Technology, Shenzhen, China.
Yiwei HuGuangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, State Key Laboratory of Tropical Oceanography, Chinese Academy of Sciences, Guangzhou, China.
Kai ZhaoGuangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, State Key Laboratory of Tropical Oceanography, Chinese Academy of Sciences, Guangzhou, China.
Wanying ZhangGuangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, State Key Laboratory of Tropical Oceanography, Chinese Academy of Sciences, Guangzhou, China.
Yue SongGuangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, State Key Laboratory of Tropical Oceanography, Chinese Academy of Sciences, Guangzhou, China.
Yonghong LiuGuangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, State Key Laboratory of Tropical Oceanography, Chinese Academy of Sciences, Guangzhou, China.
Qingchao LiuCollege of Chemical Engineering Department of Pharmaceutical Engineering, Northwest University, Xi'an, China.
Liang YangShenzhen Third People's Hospital, National Clinical Research Centre for Infectious Disease, The Second Affiliated Hospital of Southern.
Junfeng WangGuangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, State Key Laboratory of Tropical Oceanography, Chinese Academy of Sciences, Guangzhou, China.ORCID https://orcid.org/0000-0001-8914-5174

Funding

Guangdong Basic and Applied Basic Research Foundation 2022B1515120075Guangdong MEPP Funds GDNRC [2024]28Hainan Provincial Natural Science Foundation of China 823CXTD393Key-Area Research and Development Program of Guangdong ProvinceKey Science and Technology Plan Projects 2023ZD010
6 · The paper itself

Abstract

Two new natural 2-alkylquinolin-4(1H)-one derivatives, 2-(5-methylheptyl) quinolin-4(1H)-one (1) and 2-(5-methylnonane) quinolin-4(1H)-one (2), along with ten known compounds (3-12), were isolated from the strain of Bacillus rugosus SCSIO 41395, which was obtained from the sediments of the Philippine Basin. All the isolates were evaluated for bacteriostatic activities against Pseudomonas aeruginosa (PA). Compounds 4 and 5 exhibited bacteriostatic effects by inhibiting the expression of rhl, pqs, and las quorum-sensing genes, as well as suppressing related phenotypes, including rhamnolipid, pyocyanin production, and biofilm formation. Our findings suggest that compounds 4 and 5 are promising quorum-sensing inhibitors for potential alternative treatments of PA infections.

Indexed as

Anti-Bacterial AgentsBacillusPseudomonas aeruginosaQuinolonesBiofilmsMicrobial Sensitivity TestsMolecular StructureQuorum SensingStructure-Activity RelationshipAnti-Bacterial AgentsQuinolonesBacillus spmetabolitesPseudomonas aeruginosaquinolinesquorum‐sensing inhibitors

Identifiers

PMID41518657
PMCPMC13420210

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.