Evidence map›Paper›PMID 41518612›Full record

Trial reportJournal of the American Geriatrics Society2026

The "Reducing Inflammation for Greater Health Trial (RIGHT)" Study-Concept, Rationale, and Design.

Sebastian E Sattui, Marnie Bertolet, Daniel E Forman, Michelle E Danielson, Shanshan Yao, Oscar L Lopez, Nancy W Glynn, Neelesh K Nadkarni, Akira Sekikawa, Tullia C Bruno and 2 more

Abstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sebastian E SattuiDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-3945-6828
Marnie BertoletDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Daniel E FormanDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Michelle E DanielsonDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Shanshan YaoDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Oscar L LopezDepartment of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nancy W GlynnDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-2265-0162
Neelesh K NadkarniDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Akira SekikawaDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Tullia C BrunoDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Toren FinkelDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Anne B NewmanDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

PREVENTABLE Vanguard PhaseU19AG065188 · NIA · DUKE UNIVERSITY · PI Laura Kristin NEWBY · 2019 to 2026
$96.2M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
TriState SenNET (Lung and Heart) Tissue Map and Atlas consortiumU54AG075931 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TOREN FINKEL, Melanie Koenigshoff · 2021 to 2026
$14.0M
Modified Application of Cardiac Rehabilitation (CR) for Older Adults (MACRO)R01AG060499 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORMAN, DANIEL E. · 2018 to 2022
$5.0M
Home-based cardiac rehabilitation using a novel mobile health exercise regimen following transcatheter heart valve interventions (HOME RUN HITTER)R01AG073633 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Brian Richard Lindman · 2022 to 2026
$3.2M
Improving outcomes from cardiac rehabilitation among older adults through exercise testing and individualized exercise intensity prescriptionsR01AG077179 · NIA · BAYSTATE MEDICAL CENTER, INC. · PI Quinn Russell Pack · 2022 to 2026
$2.9M
Greater Houston Community FoundationNIA NIH HHS P30AG024827NIA NIH HHS R01AG060499NIA NIH HHS R01AG073633NIA NIH HHS R01AG077179NIA NIH HHS R03AG0829283NIA NIH HHS U19AG065188NIA NIH HHS U54AG075931Patient-Centered Outcomes Research Institute IHS-2021C3-24147Pittsburgh Claude D. Pepper Older Americans Independence CenterUniversity of Pittsburgh Aging InstituteVeterans Health Administration 1I21RX004409Veterans Health Administration I01HX003518Woodnext Foundation
6 · The paper itself

Abstract

The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single-center, randomized, double-blind, placebo-controlled trial designed to test whether clazkizumab, an interleukin-6 (IL-6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo. The trial will enroll participants meeting the following inclusion criteria: (1) ≥ 70 years of age, (2) with low to moderate physical function, defined as self-reported difficulty walking 1/4 mile or climbing a flight of stairs, but able to walk 400 m at baseline exam, (3) usual walking speed between ≥ 0.44 and < 1.0 m/s on a 4-m walk or a body mass index of ≥ 28 kg/m

Indexed as

Antibodies, Monoclonal, HumanizedInflammationInterleukin-6 InhibitorsAgedCognitionDouble-Blind MethodFemaleHumansInterleukin-6MaleResearch DesignAntibodies, Monoclonal, HumanizedInterleukin-6Interleukin-6 Inhibitorsagingclinical trialinflammation

Identifiers

PMID41518612
PMCPMC12968359

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.