Evidence map›Paper›PMID 41518582›Full record

ArticlePlant molecular biology2026

MsCCoAOMTh3 confers drought tolerance by mediating lignin content and ROS scavenging.

Shudi Huang, Fang Ma, Yunfei Liang, Jiaxin Wu, Zhiguo Xie, Xiangqiang Zhan, Yilin Cui, Zhichao Ma, Peizhi Yang

Abstract read
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In one paragraph

Article in Plant molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shudi Huang *College of Grassland Agriculture, Northwest A&F University, Yangling, 712100, China.
Fang Ma *College of Grassland Agriculture, Northwest A&F University, Yangling, 712100, China.
Yunfei LiangCollege of Grassland Agriculture, Northwest A&F University, Yangling, 712100, China.
Jiaxin WuCollege of Grassland Agriculture, Northwest A&F University, Yangling, 712100, China.
Zhiguo XieShaanxi Academy of Forestry, Lianhu, Xi'an, 710082, Shaanxi, China.
Xiangqiang ZhanCollege of Horticulture, Northwest A&F University, Yangling, 712100, China.
Yilin CuiCollege of Grassland Agriculture, Northwest A&F University, Yangling, 712100, China.
Zhichao MaCollege of Grassland Agriculture, Northwest A&F University, Yangling, 712100, China.
Peizhi YangCollege of Grassland Agriculture, Northwest A&F University, Yangling, 712100, China. yangpeizhi@126.com.ORCID http://orcid.org/0009-0005-3630-9899

Funding

Project of Science and Technology Innovation 2030 [2022ZD04011]
6 · The paper itself

Abstract

Caffeoyl-CoA O-methyltransferase (CCoAOMT) is a key enzyme in the phenylpropanoid pathway that plays a crucial role in lignin biosynthesis; however, its functional role in Medicago sativa remains poorly understood. In this study, we identified 44 MsCCoAOMT family members and analyzed their expression profiles across eight tissues and under polyethylene glycol (PEG)-induced osmotic stress. Among them, MsCCoAOMTh3 displayed preferential expression in roots and flowers, and was significantly upregulated in roots and stems following PEG treatment, suggesting a potential role in both plant development and stress responses. Functional validation through heterologous expression in Arabidopsis thaliana revealed that MsCCoAOMTh3 overexpression markedly increased lignin accumulation and promoted xylem development in roots. Furthermore, transgenic lines displayed enhanced drought tolerance, characterized by elevated antioxidant enzyme activity and reduced malondialdehyde (MDA) levels. Collectively, these findings suggest that MsCCoAOMTh3 acts as a positive regulator of root lignification and enhances drought tolerance by modulating both stress-responsive and lignin biosynthesis-related genes.

Indexed as

LigninMedicago sativaMethyltransferasesPlant ProteinsReactive Oxygen SpeciesArabidopsisDrought ResistanceDroughtsGene Expression Regulation, PlantMalondialdehydePlant RootsPlants, Genetically ModifiedStress, Physiologicalcaffeoyl-CoA O-methyltransferaseLigninMalondialdehydeMethyltransferasesPlant ProteinsReactive Oxygen SpeciesAlfafaCaffeoyl-CoA O-methyltransferaseDrought stressLignin

Identifiers

PMID41518582

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.