Evidence map›Paper›PMID 41518579›Full record

ArticleBulletin of experimental biology and medicine2025

Features of the Therapy of Liver Cirrhosis in Aged Male and Female Rats.

I A Uzyanbaev, O V Pershina, A V Pakhomova, E A Akhtyamova, L A Sandrikina, L V Kogai, V N Sedinova, V A Krupin

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

I A UzyanbaevGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. wertyg233@gmail.com.
O V PershinaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
A V PakhomovaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
E A AkhtyamovaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
L A SandrikinaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
L V KogaiGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
V N SedinovaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
V A KrupinGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex differences in the development of toxic liver cirrhosis in 12-month-old Wistar rats and the specific features of liver cirrhosis therapy with bovhyaluronidase azoximer were studied. The severity of pathological changes assessed by ultrasound, histological, biochemical, and hematological methods in male rats with liver cirrhosis exceeded that in female rats. The studied drug demonstrated anti-inflammatory and antifibrotic activity in aged rats with toxic liver cirrhosis, and its effect did not depend on the sex. Sex-related mechanisms may underlie the positive changes on liver cirrhosis under the influence of the test drug.

Indexed as

Liver CirrhosisLiver Cirrhosis, ExperimentalAnimalsCarbon TetrachlorideFemaleHyaluronoglucosaminidaseLiverMaleRatsRats, WistarSex FactorsCarbon TetrachlorideHyaluronoglucosaminidasebovhyaluronidase azoximercarbon tetrachlorideliver cirrhosissextreatment features

Identifiers

PMID41518579

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.