ArticleClinical oral investigations2026
Impact of postoperative radiotherapy and chemoradiotherapy on survival outcomes in oral squamous cell carcinoma patients with pN1 neck disease.
Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Oral squamous cell carcinoma arising from oral epithelial dysplasia shows high postoperative recurrence despite favorable histopathology.Clinical oral investigations · 2026Article
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6 authors.
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Abstract
backgroundThe lymph node management of oral squamous cell carcinoma (OSCC) patients with pN1 neck remains a clinical challenge. This study investigates the impact of different treatment modalities – surgery alone, surgery with postoperative radiotherapy (PORT), and surgery with postoperative chemoradiotherapy (PCRT) – on recurrence and survival outcomes in OSCC patients with pN1 neck.
methodsA retrospective cohort study was conducted on 98 patients who underwent tumor resection and neck dissection, with a subset receiving adjuvant therapy, between 2011 and 2020. Clinicopathological characteristics were examined for associations with treatment modality using chi-square test. Kaplan-Meier survival curves for overall survival (OS) and recurrence-free survival (RFS), along with the log-rank test, were employed to assess survival over a 10-year period. The prognostic significance of clinicopathological factors and treatment modalities was evaluated using Cox proportional hazards models.
resultsThe addition of PORT following surgery significantly reduced the risk of recurrence (HR = 0.280, p = 0.010) and enhanced RFS, particularly at 10 years (p = 0.010). PORT was also associated with a statistically significant improvement in 5-year-OS (p = 0.031) compared to surgery alone, with a trend toward improved OS at 10 years (p = 0.175). In contrast, surgery alone did not yield comparable 10-year survival outcomes. Additionally, the inclusion of PCRT did not show a distinct survival advantage over the combination of surgery and PORT.
conclusionOur results indicate that PORT may be considered the standard adjuvant treatment for these patients, as it improves RFS, particularly in the long term, while the addition of chemotherapy does not provide significant additional benefits over PORT alone.
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