ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026
Molecular characterization of Neisseria meningitidis isolates from healthy individuals in Meigu County, Sichuan Province, 2021-2024.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To explore the molecular characteristics of Neisseria meningitidis carried by healthy individuals in Meigu County, Liangshan Yi Autonomous Prefecture, Sichuan Province, and to provide scientific evidence for preventing and controlling epidemic meningitis, this study analyzed 240 N. meningitidis isolates collected from 2021 to 2024. PCR-based genogrouping and second-generation whole-genome sequencing (WGS) were performed. The results showed that genogroup B was the most common, accounting for 65%. Multilocus Sequence Typing(MLST) analysis identified 78 sequence types(STs), with ST-18,628 and ST-2146 being the most frequent. Notably, 41% of the STs (ST-18,620 to ST-18,856) were newly identified. While 29 STs were allocated to six known clonal complexes, 49 STs couldn't be assigned to any. Genogroup B N. meningitidis (MenB) isolates showed high heterogeneity and the most common clonal complexes were CC4821, CC175, CC198. The NG N. meningitidis isolates were predominately CC198, CC4821, CC5. Genogroup W N. meningitidis (MenW) isolates were predominately CC4821. Genogroup Y N. meningitidis (MenY) isolates were belonged to CC175.Three AMR genes were detected, with mtrC and mtrD having the highest detection rate. Also, sixty-eight virulence genes were found. Core genome SNP analysis indicated same-year isolates clustered phylogenetically. In conclusion, the N. meningitidis isolates in Meigu County have diverse virulence genes and a high rate of novel STs, showing a regional epidemic trend, and continuous monitoring is necessary.
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