Evidence map›Paper›PMID 41518526›Full record

Trial reportEuropean journal of pediatrics2026

Daycare-simulated interrupted phototherapy for neonatal jaundice: a randomized controlled trial.

Jia Cheng Ong, Farohah Che Mat Zain, Yee Cheng Kueh, Noraida Ramli, Hans Van Rostenberghe, Surini Yusoff

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jia Cheng OngDepartment of Paediatrics, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, 16150, Malaysia.ORCID http://orcid.org/0009-0007-3346-0950
Farohah Che Mat ZainDepartment of Paediatrics, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, 16150, Malaysia.ORCID http://orcid.org/0009-0001-0293-4857
Yee Cheng KuehBiostatistics & Research Methodology Unit, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, 16150, Malaysia.ORCID http://orcid.org/0000-0003-2125-7297
Noraida RamliDepartment of Paediatrics, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, 16150, Malaysia.ORCID http://orcid.org/0000-0003-1957-4584
Hans Van RostenbergheDepartment of Paediatrics, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, 16150, Malaysia.
Surini YusoffDepartment of Paediatrics, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, 16150, Malaysia. surini@usm.my.ORCID http://orcid.org/0000-0003-1274-0930

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to compare the effectiveness of daycare-simulated interrupted phototherapy versus continuous phototherapy for treating neonatal jaundice. A parallel randomized controlled trial with one-to-one allocation was conducted involving low-risk jaundiced neonates. The neonates in the intervention group received 10 h of phototherapy, while the control group received continuous phototherapy for 24 h. Total serum bilirubin (TSB) was measured before the start of phototherapy and at 24 h of treatment. Seventy-four neonates were recruited, and 37 neonates were randomly allocated to each group. The mean rate of fall of TSB per hour was not statistically significantly different between the intervention and control groups (1.71 versus 1.9 µmol/L/h; p = 0.529). The mean of TSB post-treatment in the intervention group was higher than in the control group and statistically significant (182 versus 158 µmol/L; p = 0.045) but not clinically significant, as none of the neonates required reinstitution or continuation of phototherapy.

conclusionTen hours of phototherapy which could be given in daycare may be effective and safe.

trial registrationThis trial wasregistered with Australian New Zealand Clinical Trials (trial ID: ANZCTR 12624000860561) prospectively on 12 July 2024. WHAT IS KNOWN: • Intermittent phototherapy is known to be as effective as continuous phototherapy. WHAT IS NEW: • We designed a study in which phototherapy was interrupted after 10 h, simulating daycare phototherapy. • Daycare phototherapy for 10 h may be feasible in treating neonatal hyperbilirubinemia in low-risk neonates.

Indexed as

Jaundice, NeonatalPhototherapyBilirubinFemaleHumansInfant, NewbornMaleTreatment OutcomeBilirubinContinuous phototherapyDaycareInterrupted phototherapyNeonatal jaundice

Identifiers

PMID41518526
PMCPMC12790534

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.