Evidence map›Paper›PMID 41518493›Full record

Observational studyEuropean geriatric medicine2026

Impact of delirium subtypes on survival in older adults hospitalised for acute heart failure: a prospective study in an acute geriatric unit.

Alberto Finazzi, Chukwuma Okoye, Elena Pinardi, Alice Margherita Ornago, Maria Cristina Ferrara, Emma Esposito, Martina Marelli, Eleonora Cucini, Martina Manna, Elena Page and 2 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alberto Finazzi *School of Medicine and Surgery, University of Milano-Bicocca, Milan Via Pergolesi, 33, 20900, Monza, (MB) Milano, Italy. a.finazzi15@campus.unimib.it.ORCID http://orcid.org/0009-0005-5284-9588
Chukwuma Okoye *School of Medicine and Surgery, University of Milano-Bicocca, Milan Via Pergolesi, 33, 20900, Monza, (MB) Milano, Italy.
Elena PinardiSchool of Medicine and Surgery, University of Milano-Bicocca, Milan Via Pergolesi, 33, 20900, Monza, (MB) Milano, Italy.
Alice Margherita OrnagoAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Maria Cristina FerraraSchool of Medicine and Surgery, University of Milano-Bicocca, Milan Via Pergolesi, 33, 20900, Monza, (MB) Milano, Italy.
Emma EspositoSchool of Medicine and Surgery, University of Milano-Bicocca, Milan Via Pergolesi, 33, 20900, Monza, (MB) Milano, Italy.
Martina MarelliSchool of Medicine and Surgery, University of Milano-Bicocca, Milan Via Pergolesi, 33, 20900, Monza, (MB) Milano, Italy.
Eleonora CuciniSchool of Medicine and Surgery, University of Milano-Bicocca, Milan Via Pergolesi, 33, 20900, Monza, (MB) Milano, Italy.
Martina MannaFondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
Elena PageSchool of Medicine and Surgery, University of Genoa, Genoa, Italy.
Adriana Antonella BruniFondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
Giuseppe BellelliSchool of Medicine and Surgery, University of Milano-Bicocca, Milan Via Pergolesi, 33, 20900, Monza, (MB) Milano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDelirium is a common complication in older adults hospitalised for acute heart failure (AHF), but its incidence, subtypes, and short-term outcomes remain poorly characterised in the very old population. This study aimed to determine the prevalence and incidence of delirium in patients admitted to an acute geriatric unit (AGU) with AHF, describe its subtypes, and assess their impact on 90-day post-discharge survival.

methodsThis prospective observational study included older adults hospitalised for AHF in an AGU between April 2022 and November 2024. Delirium was assessed using the 4AT and DSM-5 criteria and categorised as prevalent (on admission) or incident (during hospitalisation). Delirium psychomotor subtypes were classified as hyperactive, hypoactive, or mixed. Sociodemographic, clinical, and follow-up data were collected. Ninety-day survival was evaluated using Kaplan-Meier curves and Cox regression models.

resultsAmong 399 patients (median age 87.4 years, 52% female), 132 (33%) experienced delirium, with 13.8% classified as prevalent and 19.2% as incident cases. Among those with delirium, 48% presented with the hyperactive, 31% with hypoactive, and 21% with the mixed subtype. In multivariable regression analysis, adjusted for relevant covariates, the hypoactive (adjusted HR 2.03, 95% CI 1.13-3.64) and mixed (adjusted HR 2.28, 95% CI 1.18-4.43) subtypes-but not the hyperactive subtype-were independently associated with an increased risk of death.

conclusionsDelirium is common in very old patients hospitalised for AHF. Our findings indicate that the hypoactive and mixed subtypes are independently associated with poor 90-day post-discharge survival, highlighting the importance of their active identification and management.

Indexed as

DeliriumHeart FailureHospitalizationAcute DiseaseAgedAged, 80 and overFemaleHumansIncidenceMalePrevalenceProspective StudiesAcute heart failureDelirium subtypesMortalityOlder adults

Identifiers

PMID41518493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.