Evidence map›Paper›PMID 41518468›Full record

ReviewApoptosis : an international journal on programmed cell death2026

Unveiling estrogen's role: a comprehensive review of its impact on skin health and disease.

Yi Li, Nan Deng, Xin Luo, Yadan Tan, Ziteng Huang, Yi Liu, Jinshan Xing, Yongqiu Zeng, Jingyan Yi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Apoptosis : an international journal on programmed cell death, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yi Li *Department of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Nan Deng *Luzhou People's Hospital, Luzhou, 646000, Sichuan, China.
Xin Luo *Key Laboratory of Luminescence Analysis and Molecular Sensing, School of Materials and Energy, Southwest University, Chongqing, 400715, China.
Yadan TanDepartment of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Ziteng HuangDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Yi LiuDepartment of Neurosurgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Jinshan XingDepartment of Neurosurgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China. xingjinshan2020@swmu.edu.cn.
Yongqiu ZengDepartment of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan, China. yongqiu120@swmu.edu.cn.
Jingyan YiDepartment of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Key Laboratory of Medical Electrophysiology, Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, Sichuan, China. jingyany@swmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the application of estrogen in skin health and disease prevention has garnered significant attention, and it is now widely involved in the intervention and study of various skin conditions. Experimental evidence shows that estrogen has profound effects on the structure and function of the skin, including the synthesis of collagen and elastin, regulation of skin pigmentation, and control of sebum secretion. This review systematically summarizes the multifaceted effects of estrogen on skin health and diseases, with a focus on the mechanisms by which different types of estrogen influence skin aging, pigmentation, and other related issues. Additionally, we explore how estrogen exerts its effects on the skin through various signaling pathways, such as estrogen receptor-mediated signaling, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), and mitogen-activated protein kinase (MAPK) pathways. Through a comprehensive analysis of the existing studies, this review aims to provide a deeper understanding of the complex interactions between estrogen and the skin, offering a comprehensive perspective on estrogen's role in skin physiology and pathology.

Indexed as

EstrogensSkinSkin DiseasesAnimalsHumansProto-Oncogene Proteins c-aktReceptors, EstrogenSignal TransductionSkin AgingSkin PigmentationEstrogensProto-Oncogene Proteins c-aktReceptors, EstrogenAging repairDrug developmentEstrogenSignaling pathwaysSkin disease

Identifiers

PMID41518468

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.