Observational studyEuropean journal of pediatrics2026
Single-center study of vancomycin treatment in children with infection: influencing factors of plasma trough concentration and assessment of clinical effectiveness.
Observational study in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
4 authors.
Funding
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Abstract
Achieving optimal vancomycin trough concentrations in vivo is crucial to its therapeutic effectiveness. This study was a retrospective, single-center, observational cohort analysis designed to further investigate factors affecting vancomycin trough levels and adverse reactions in pediatric patients with infections, building upon previous research on the rational pediatric use. Additionally, we explored the relationship between vancomycin trough levels and clinical symptom improvement in children infected with Methicillin-resistant Staphylococcus aureus (MRSA). The findings demonstrated that initial vancomycin dosing regimens, as well as serum albumin, hemoglobin, alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase levels, did not differ significantly among the three trough concentration groups: target (10-20 mg/L), high (≥ 20 mg/L), and low (< 10 mg/L) (P > 0.05). The estimated glomerular filtration rate (GFR) values at treatment initiation were 108.4 (87.8-163.7), 95.2 (65.8-144.3), and 149.8 (95.3-201.6) for the three groups, respectively (P < 0.05). Multiple linear regression identified GFR as the most predictive variable for vancomycin trough concentration, showing a negative linear correlation with the initial GFR value in children undergoing vancomycin treatment (R
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Registered trials
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