Evidence map›Paper›PMID 41518428›Full record

ReviewCurrent gastroenterology reports2026

A Historical and Scientific Review of Anti-Reflux Surgery: Evolution, Evidence, and Future Directions.

Moustafa Elshafei, Sjaak Pouwels, Andreas Pascher, Jens Peter Hoelzen, Mazen A Juratli

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current gastroenterology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Moustafa ElshafeiDepartment of General, Abdominal and Tumor Surgery, St. Elisabethen Krankenhaus, Frankfurt am Main, Hessen, Germany.
Sjaak PouwelsDepartment of Surgery, University Medical Center OWL of Bielefeld University - Campus Klinikum Lippe, Detmold, NRW, Germany. sjaakpwls@gmail.com.
Andreas PascherDepartment of General, Visceral and Transplant Surgery, University Hospital Muenster, Muenster, 48149, Germany.
Jens Peter HoelzenDepartment of General, Visceral and Transplant Surgery, University Hospital Muenster, Muenster, 48149, Germany.
Mazen A JuratliDepartment of General, Visceral and Transplant Surgery, University Hospital Muenster, Muenster, 48149, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewGastroesophageal Reflux Disease (GERD) is a condition, which is frequently encountered by gastroenterologists, otorhinolaryngologists, surgeons and general physicians and requires a multidisciplinary treatment when there is a high symptom burden in patients. Besides lower oesophageal sphincter (LES) dysfunction there are several other risk factors that contribute to the development and symptoms (worsening) of GERD. While these lifestyle modifications and pharmacological therapies, particularly proton pump inhibitors (PPIs), are first-line treatments, a subset of patients requires surgical intervention due to refractory symptoms or complications. This review traces the evolution of anti-reflux surgery, examining its historical milestones, advancements, and future prospects. RECENT

findingsThis review discusses the epidemiology of GERD, its pathophysiology, but also the development of Anti-Reflux Surgery (ARS). We will discuss the available evidence regarding different ARS procedures and will focus on individualised treatment for patients with GERD. In the treatment of patients with GERD we have to take into account that it might be challenging to personalise treatment and therefore optimise results. In this instance special considerations need to be taken for patients with GERD and obesity, patients with Barretts oesophagus, patients after bariatric and metabolic surgery (BMS) and patients with oesophageal motility disorders.

Indexed as

FundoplicationGastroesophageal RefluxEsophageal Sphincter, LowerHistory, 20th CenturyHistory, 21st CenturyHumansProton Pump InhibitorsProton Pump InhibitorsAnti-reflux surgeryDorr fundoplicationGastro-Oesophageal reflux diseaseGERDMagnetic sphincter augmentationMinimally invasive surgeryNissen fundoplicationRobotic surgery

Identifiers

PMID41518428

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.