Evidence map›Paper›PMID 41518411›Full record

ArticleJournal of neurology2026

Integrating functional network topology, synaptic density, and tau pathology to predict cognitive decline in amnestic mild cognitive impairment.

Chih-Hao Lien, Greet Vanderlinden, Thomas Vande Casteele, Maarten Laroy, Margot G A Van Cauwenberge, Kristof Vansteelandt, Michel Koole, Ronald Peeters, Stefan Sunaert, Filip Bouckaert and 4 more

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Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chih-Hao Lien *Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Greet Vanderlinden *Nuclear Medicine, Department of Imaging and Pathology, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Thomas Vande CasteeleNeuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Maarten LaroyNeuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Margot G A Van CauwenbergeNeuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Kristof VansteelandtGeriatric Psychiatry, University Psychiatric Center, KU Leuven, 3000, Leuven, Belgium.
Michel KooleNuclear Medicine, Department of Imaging and Pathology, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Ronald PeetersTranslational MRI, Department of Imaging and Pathology, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Stefan SunaertTranslational MRI, Department of Imaging and Pathology, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Filip BouckaertNeuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Louise EmsellNeuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Koen Van LaereNuclear Medicine, Department of Imaging and Pathology, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Jan Van den Stock *Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Mathieu Vandenbulcke *Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium. mathieu.vandenbulcke@kuleuven.be.

Funding

Fonds Wetenschappelijk Onderzoek 1292326NFonds Wetenschappelijk Onderzoek FWO/G093218NKU Leuven C24-17-063
6 · The paper itself

Abstract

backgroundAmnestic mild cognitive impairment (aMCI) represents a prodromal stage of Alzheimer's disease and carries a high risk of progression to dementia. Disruptions in functional brain networks, synaptic degeneration, and tau pathology each serve as neural markers of cognitive decline in aMCI. In this study, we employed a multimodal neuroimaging approach to determine whether integrating these markers provides a more powerful explanation of cognitive deterioration than examining them individually.

methodsTwenty-eight aMCI patients and 24 healthy controls underwent cognitive assessment, resting-state fMRI,

resultsLongitudinal changes in right hippocampal characteristic path length, synaptic density, and tau accumulation jointly predicted decline in delayed memory recall, achieving a higher predictive performance (adjusted R

conclusionsMultimodal neuroimaging integrating functional network topology, synaptic density, and tau burden improves prediction of memory decline in aMCI. These findings highlight complementary neural processes underlying progression and support multimodal imaging as a valuable approach for monitoring in prodromal Alzheimer's disease.

Indexed as

AmnesiaBrainCognitive DysfunctionNerve NetSynapsestau ProteinsAgedDisease ProgressionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultimodal ImagingNeuropsychological TestsPositron-Emission Tomographytau ProteinsAmnestic mild cognitive impairment (aMCI)Network topologyPositron emission tomography (PET)Resting-state fMRI (rs-fMRI)Synaptic densityTau

Identifiers

PMID41518411

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.