Evidence map›Paper›PMID 41518307›Full record

ArticleJournal of chemical information and modeling2026

Curated and Structure-Based Drug-Target Interactions Improve Underprediction of Drug Side Effects in Network Models.

Mohammadali Alidoost, Amy Le, Jennifer L Wilson

Abstract read
In one paragraph

Article in Journal of chemical information and modeling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mohammadali AlidoostDepartment of Bioengineering, University of California, Los Angeles (UCLA), 410 Westwood Plaza, Los Angeles, California 90095, United States.ORCID 0000-0003-2042-8736
Amy LeDepartment of Bioengineering, University of California, Los Angeles (UCLA), 410 Westwood Plaza, Los Angeles, California 90095, United States.
Jennifer L WilsonDepartment of Bioengineering, University of California, Los Angeles (UCLA), 410 Westwood Plaza, Los Angeles, California 90095, United States.ORCID 0000-0002-2328-2018

Funding

Understanding cascading cellular protein responses following multi-protein stimuli using network modeling and real-world evidenceR35GM147114 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jennifer Lynn Wilson · 2022 to 2026
$1.6M
NIGMS NIH HHS R35 GM147114
6 · The paper itself

Abstract

The accurate prediction of drug-induced side effects remains a significant challenge in pharmaceutical development, particularly in early development, as drug programs often fail due to unforeseen adverse reactions. Conventional approaches, such as preclinical animal testing and

Indexed as

Drug-Related Side Effects and Adverse ReactionsProteinsBiocurationDrug DiscoveryHumansPrediction AlgorithmsProteins

Identifiers

PMID41518307
PMCPMC13225765

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.