One-Pot Transition-Metal-Free Methods for the Synthesis of All Three Bonds of the Alkyne's Triple Bond.

Eugene Kim, Yu Wu, Judith N Currano, Jianyou Mao, Patrick J Walsh

Abstract readReview

In one paragraph

Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eugene KimDepartment of Chemistry, University of Pennsylvania, 213 S. 34th St., Philadelphia, PA, 10104, USA.

Yu WuDepartment of Chemistry, University of Pennsylvania, 213 S. 34th St., Philadelphia, PA, 10104, USA.

Judith N CurranoDepartment of Chemistry, University of Pennsylvania, 213 S. 34th St., Philadelphia, PA, 10104, USA.ORCID https://orcid.org/0000-0002-3666-5966

Jianyou MaoSchool of Chemistry and Molecular Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing, 211816, P. R. China.

Patrick J WalshDepartment of Chemistry, University of Pennsylvania, 213 S. 34th St., Philadelphia, PA, 10104, USA.ORCID https://orcid.org/0000-0001-8392-4150

Funding

American Chemical Society Petroleum Research Fund 67280-ND1Directorate for Mathematical and Physical Sciences CHE-2154593Jiangsu Provincial Key Research and Development Program . BE2023333

6 · The paper itself

Abstract

Alkynes are among the most useful functional groups in synthetic chemistry, as they are excellent starting materials for various reactions and serve as valuable precursors during total synthesis. Despite the high number of transformations that utilize alkynes as substrates, few methods actually exist to synthesize them. Known methods involve several synthetic steps, harsh conditions, or cryogenic temperatures, which render them inconvenient and inefficient. This review of alkyne syntheses cover methods that enable the formation of all three bonds of the alkyne's triple bond in a transition-metal-free, one-pot fashion. This review offers a guide to gauge if current methods are potentially suitable to be scaled and used in industry and pharmaceutical processes.

Indexed as

acetylenesinternal alkynesone‐pot synthesesSonogashira cross‐couplingterminal alkynes

Identifiers

PMID41518280

DOI10.1002/chem.202503062

PMCPMC12995854

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.