Evidence map›Paper›PMID 41518128›Full record

ArticleMovement disorders clinical practice2026

Psychiatric Comorbidity, Tic Severity and Quality of Life in Adults with Tourette's Syndrome.

Andreas Hartmann, Christelle Nilles, Yulia Worbe, Davide Martino, Naoual Serari, Catherine Deans, Isabella Davenport, Julian Fletcher, Emmanuel Roze, Tamara Pringsheim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andreas HartmannCentre de Référence National Maladie Rare "Syndrome Gilles de la Tourette," Hôpital de la Pitié-Salpêtrière, Paris, France.
Christelle NillesDepartment of Neurology, Hôpital Fondation Rothschild, Paris, France.
Yulia WorbeCentre de Référence National Maladie Rare "Syndrome Gilles de la Tourette," Hôpital de la Pitié-Salpêtrière, Paris, France.
Davide MartinoDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Naoual SerariInstitut de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.
Catherine DeansDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Isabella DavenportDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Julian FletcherDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Emmanuel RozeInstitut de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.
Tamara PringsheimDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.

Funding

French Gilles de la Tourette AssociationTourette OCD Alberta NetworkUniversity of Calgary Owerko Centre
6 · The paper itself

Abstract

backgroundPsychiatric comorbidities are common in adults with Tourette's Syndrome (TS), and appear to influence both tic severity and quality of life (QOL).

objectiveTo assess the association between psychiatric comorbidities, tic severity and QOL in TS.

methodsWe used data from 227 participants in the Calgary and Paris Adult Tic Disorders Clinical Registry. Our aim was to investigate how comorbid psychiatric symptoms impact tic severity, impairment, and QOL. We measured tic severity and impairment with the Yale Global Tic Severity Scale (YGTSS), and QOL with the Gilles de la Tourette Quality of Life Scale (GTS-QOL). Psychiatric symptom severity was assessed using self-report questionnaires: Patient Health Questionnaire 9 (PHQ9) for depression, Generalized Anxiety Disorder 7 (GAD7), Adult ADHD Self-Report Scale (ASRS), and Obsessive-Compulsive Inventory Revised (OCI-R).

resultsTic severity was higher in participants with ADHD, GAD, or depression, with significant correlations between psychiatric symptom scores and YGTSS scores. Linear regression showed that only the severity of depressive symptoms was significantly associated with tic severity and impairment. Both tic severity and psychiatric symptom severity scores correlated positively with the GTS-QOL Total Score and subscale scores. Depressive symptoms had the strongest correlation with GTS-QOL Total Score, followed by ADHD. Linear regression of GTS-QOL Total scores revealed significant relationships with all symptom severity variables.

conclusionBoth tic severity and, notably, depression and ADHD, significantly impact QOL. These interactions are complex, underlining the critical need for multidisciplinary care for adults with TS.

Indexed as

Mental DisordersQuality of LifeTicsTourette SyndromeAdolescentAdultAttention Deficit Disorder with HyperactivityComorbidityDepressionFemaleGeneralized Anxiety DisorderHumansMaleMiddle AgedPsychiatric Status Rating ScalesSeverity of Illness IndexADHDdepressionquality of lifeticsTourette's syndrome

Identifiers

PMID41518128
PMCPMC13306895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.