SynthesisPhytotherapy research : PTR2026
Nanoemulsions for Skin Delivery of Essential Oils: A Systematic Review.
Synthesis in Phytotherapy research : PTR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Formulation Attributes and Preclinical Wound Healing Outcomes of Natural Product Based Nanoemulsions: A Systematic Review.International journal of nanomedicine · 2026Pooled it
- Candicidal Effect of a Nanoemulsion Based on the Essential Oil of the Medicinal PlantPharmaceuticals (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Essential oils (EOs) are recognized for their multiple health benefits. However, their high volatility, low stability, and limited water solubility limit their effective application. This systematic review aims to assess the use of nanoemulsions as delivery systems for the topical administration of EOs, highlighting their efficacy, safety, and limitations. A literature search was conducted in the PubMed, Scopus, and Web of Science databases for studies published in English before February 2025, following the PRISMA 2020 guidelines. Studies limited to in vitro or ex vivo assays, using isolated EO components, or involving non-topical applications were excluded. Twenty-two articles were included in this review, comprising EOs from 18 plant species, and applied in animal or human in vivo models for wound healing (n = 6), anti-inflammatory/analgesic effects (n = 5), cosmetic (n = 6), and transdermal delivery/permeation enhancer (n = 5). Nanoemulsions improved EOs' bioactivities, particularly their anti-inflammatory, antioxidant, and antimicrobial effects, by enhancing skin permeation, bioavailability, and skin barrier function, reducing skin irritation, and allowing a controlled release. However, the overall risk of bias, assessed using the SYRCLE and RoB 2 tools, was considered high, and the studies' heterogeneity limited direct comparisons. Therefore, further well-designed preclinical and clinical trials are needed to validate these findings and assess the potential of the EOs nanoemulsions for topical use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.