ArticleChembiochem : a European journal of chemical biology2026
Selection and Characterization of SARS-CoV-2 Spike Binding Clickmers.
Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Selection and Characterization of SARS-CoV-2 Spike Binding Clickmers.Chembiochem : a European journal of chemical biology · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Expanding the chemical repertoire of canonical nucleotides is key to unlocking the full functional potential of aptamers for diagnostic use. Herein, click-systematic evolution of ligands by exponential enrichment (SELEX) is employed to generate chemically modified DNA aptamers, termed clickmers, that target the SARS-CoV-2 spike (CoV2-S) glycoprotein. Two independent split-combine selection strategies yield distinct clickmer families functionalized with benzofuran or indole moieties. Lead candidates (BF1 and N2) demonstrate nanomolar affinity for wild-type CoV2-S and maintain binding to multiple variants, including Alpha, Delta, and Mu, as validated by flow cytometry, surface plasmon resonance, and microscale thermophoresis. Structure-function analysis reveals essential click-in positions for both full-length clickmers and a truncated N2 variant, as short as 31 nucleotides, which displays increased binding to the Omicron variant. These results highlight the versatility of the click-SELEX platform and exemplify its successful application to a clinically relevant target, advancing previous developments in the field.
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Registered trials
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