ArticleAnnals of medicine2026
The association between serum iodine concentration in the first trimester and foetal ultrasound biometric parameters and birth size among Chinese pregnant women.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the relationship between first-trimester maternal serum iodine concentration (SIC) and foetal ultrasound biometric parameters as well as neonatal size at birth in Chinese pregnant women. MATERIALS AND
methodsA birth cohort study of 1881 women from 2022 to 2024 in Zhejiang Province, China, was conducted. SIC in the first trimester was measured using inductively coupled plasma mass spectrometry. Foetal biometric parameters in mid-pregnancy were measured using ultrasound scanning techniques. Neonatal anthropometric measurements were obtained immediately after delivery. Linear regression models were used to explore the association between maternal SIC and both foetal ultrasound biometric parameters as well as birth size indicators.
resultsLog-transformed maternal SIC showed a significant positive association with biparietal diameter (BPD) (β = 0.102, 95% CI: 0.029, 0.174), but significant negative associations with birth length (β = -0.337, 95% CI: -0.608, -0.066) and birth weight (β = -0.091, 95% CI: -0.171, -0.012). Further sex-stratified analysis revealed that among male foetuses, SIC was significantly positively associated with BPD (β = 0.158, 95% CI: 0.053, 0.263), head circumference (HC) (β = 0.414, 95% CI: 0.074, 0.754) and abdominal circumference (AC) (β = 0.490, 95% CI: 0.111, 0.870). but negatively associated with neonatal length (β = -0.402, 95% CI: -0.742, -0.062) and birth weight (β = -0.120, 95% CI: -0.234, -0.005). These associations were attenuated and non-significant in female foetuses. Maternal age stratification showed significantly stronger positive associations between SIC and foetal BPD in women aged <29 years (β = 0.150, 95% CI: 0.036, 0.265) compared to those ≥29 years.
conclusionsOur findings suggest that first-trimester maternal SIC shows a positive association with foetal BPD but a potential negative association with neonatal anthropometric measures, with these relationships appearing stronger in male foetuses and younger mothers.
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