Evidence map›Paper›PMID 41517836›Full record

ArticleJournal of cosmetic dermatology2026

Neural Distribution-Guided Botulinum Toxin Injection for Platysma muscle: A Split-Neck Comparison With Conventional Technique.

Kyu-Ho Yi, Isaac Kai Jie Wong, Irwan Junawanto, Gi-Woong Hong, Han Earl Lee, Jovian Wan

Abstract readComparative Study
In one paragraph

Article in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kyu-Ho YiDivision in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.ORCID https://orcid.org/0000-0001-5572-1364
Isaac Kai Jie WongThe Artisan Clinic Private Limited, Singapore, Singapore.
Irwan JunawantoPrivate Practice, Jakarta, Indonesia.
Gi-Woong HongSamskin Plastic Surgery Clinic, Seoul, Korea.
Han Earl LeeOpening Plastic Surgery Clinic, Seoul, Korea.
Jovian WanMedical Research Inc., Wonju, Korea.ORCID https://orcid.org/0009-0003-2507-4524

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe platysma muscle plays a pivotal role in the formation of vertical neck bands and contributes to lower facial descent, making it a prime target for botulinum toxin type A (BoNT-A) in aesthetic neck rejuvenation. Conventional protocols typically involve injecting across the entire muscle, necessitating a high number of injection points and larger total doses, which may increase the risk of bruising, patient discomfort, and potential immunogenicity. Recent anatomical studies using Sihler's staining have demonstrated that motor innervation is predominantly concentrated in the upper portion of the platysma.

aimsTo evaluate a neural distribution-based BoNT-A injection strategy targeting only the motor-rich upper platysma, compared with the conventional whole-muscle injection approach.

methodsFifteen patients with prominent platysmal bands received BoNT-A injections (JETEMA THE TOXIN, JETEMA Inc., Korea) in a split-side design: The right platysma was injected using a conventional 30-point technique, and the left platysma received 15 targeted injections in the upper portion based on mapped motor entry points. Efficacy was assessed by the degree of platysmal band relaxation at follow-up.

resultsBoth techniques achieved comparable improvement in platysmal band appearance, despite the targeted side requiring 50% fewer injection points.

conclusionsMotor innervation-guided BoNT-A injections may achieve equivalent clinical outcomes while reducing injection burden, toxin dose, and complication risk.

Indexed as

Botulinum Toxins, Type ACosmetic TechniquesNeck MusclesNeuromuscular AgentsSkin AgingSuperficial Musculoaponeurotic SystemAdultFemaleHumansInjections, IntramuscularMaleMiddle AgedNeckRejuvenationTreatment OutcomeBotulinum Toxins, Type ANeuromuscular Agentsbotulinum toxinsinjectionsintramuscularneck muscles/innervationplatysmarejuvenationtype a

Identifiers

PMID41517836
PMCPMC12789713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.