ArticleJournal of clinical neurology (Seoul, Korea)2026
Chronic Migraine Is Associated With Region-Specific High-Grade Enlarged Perivascular Spaces: Retrospective Matched Case-Control Study.
Article in Journal of clinical neurology (Seoul, Korea), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Periventricular diffusivity at the ventricular-parenchymal interface across healthy controls, episodic migraine, and chronic migraine: a cross-sectional multimodal MRI study.The journal of headache and pain · 2026Article
- New Directions in Migraine Pathophysiology: The Glymphatic System and PACAP.Life (Basel, Switzerland) · 2026Review
- Non-neuronal targets for migraine therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
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Authors and funding
3 authors.
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Abstract
background and purposeEnlarged perivascular spaces (EPVS) observed on magnetic resonance imaging (MRI) reflect impaired glymphatic system (GS) function; however, their association with chronic migraine remains unclear. This study aimed to investigate whether chronic migraine is associated with a high burden of region-specific high-grade EPVS.
methodsThis retrospective case-control study included 44 patients with chronic migraine, 44 age- and sex-matched patients with episodic migraine, and 39 matched healthy controls. Brain MRI scans were assessed for EPVS in the centrum semiovale (CS), basal ganglia, and midbrain (MB) using a validated visual rating scale. High-grade EPVS was defined according to region-specific criteria. Logistic regression analyses were performed to evaluate the association between chronic migraine and high-grade EPVS, adjusting for age, sex, hypertension, alcohol consumption, and insomnia.
resultsThe prevalence of high-grade EPVS in the CS and MB differed significantly among the chronic migraine, episodic migraine, and control groups. Post-hoc analysis revealed a significantly higher prevalence in the chronic migraine group compared to controls in both regions, and compared to the episodic migraine group in the CS. Chronic migraine was independently associated with high-grade EPVS in the CS (adjusted odds ratio [OR]=9.345,
conclusionsChronic migraine is associated with an increased prevalence of high-grade EPVS in specific brain regions, suggesting an underlying GS dysfunction. Thus, EPVS is a potential imaging biomarker of chronic migraine.
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