Evidence map›Paper›PMID 41517652›Full record

ArticleBMJ open ophthalmology2022

Subretinal drusenoid deposits are strongly associated with coexistent high-risk vascular diseases.

Gerardo Ledesma-Gil, Oscar Otero-Marquez, Sharmina Alauddin, Yuehong Tong, Katy Tai, Harriet Lloyd, Micaela Koci, Maria Scolaro, Cinthi Pillai, Catherine Ye and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Gerardo Ledesma-Gil *Retina Department, Institute of Ophthalmology Fundación Conde de Valenciana, Mexico City, Mexico.
Oscar Otero-Marquez *Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sharmina AlauddinNew York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.
Yuehong TongDepartment of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Katy TaiNew York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.
Harriet LloydNew York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.
Micaela KociNew York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.
Maria ScolaroVitreous Retina Macula Consultants of New York, New York, New York, USA.
Cinthi PillaiNYU Grossman School of Medicine, New York, New York, USA.
Catherine YeNew York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.
Arun GovindaiahiHealthscreen Inc, New York, New York, USA.
Alauddin BhuiyanDepartment of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Mandip S DhamoonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Avnish DeobhaktaDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.
Gareth LemaDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.
Jagat NarulaDepartment of Cardiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Richard B RosenOphthalmology, NYU School of Medicine, New York, New York, USA.
Lawrence A YannuzziVitreous Retina Macula Consultants of New York, New York, New York, USA.
K Bailey FreundNYU Grossman School of Medicine, New York, New York, USA.
Roland Theodore SmithDepartment of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA RTS1MD@GMAIL.COM.ORCID http://orcid.org/0000-0002-1693-943X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsDemonstrate that subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are linked to coexistent high-risk vascular diseases (HRVDs).

methodsCross-sectional study. Two hundred AMD subjects (aged 51-100 years; 121 women, 79 men) were recruited. Spectral domain optical coherence tomography, autofluorescence and near-infrared reflectance imaging, and lipid profiles were obtained. Subjects were assigned by health history questionnaires into those with or without HRVDs, defined as: cardiac valve defect (eg, aortic stenosis), myocardial defect (eg, myocardial infarction) and stroke/transient ischaemic attack. Masked readers assigned subjects into two groups: SDD (with or without drusen) and drusen (only). Univariate testing was performed by χ

resultsThe prevalence of HRVD was 41.2% (40/97) and 6.8% (7/103) in the SDD and non-SDD groups, respectively (correlation of SDD with HRVD, p=9×10

conclusionsHigh-risk cardiovascular and neurovascular diseases were accurately identified in an AMD cohort from SDDs and HDL levels. The SDDs may be related to inadequate ocular perfusion resulting from the systemic vasculopathies. Further research with this paradigm is warranted and might reduce mortality and morbidity from vascular disease.

Indexed as

ImagingMaculaRetina

Identifiers

PMID41517652
PMCPMC9723897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.