Evidence map›Paper›PMID 41517524›Full record

ArticleJournal of clinical medicine2025

Emerging Oculomic Signatures: Linking Thickness of Entire Retinal Layers with Plasma Biomarkers in Preclinical Alzheimer's Disease.

Ibrahim Abboud, Emily Xu, Sophia Xu, Aya Alhasany, Ziyuan Wang, Xiaomeng Wu, Natalie Astraea, Fei Jiang, Zhihong Jewel Hu, Jane W Chan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ibrahim AbboudDoheny Image Analysis Laboratory, Doheny Eye Institute, 150 N. Orange Grove Blvd., Pasadena, CA 91103, USA.
Emily XuDoheny Image Analysis Laboratory, Doheny Eye Institute, 150 N. Orange Grove Blvd., Pasadena, CA 91103, USA.ORCID 0009-0003-2194-342X
Sophia XuDoheny Image Analysis Laboratory, Doheny Eye Institute, 150 N. Orange Grove Blvd., Pasadena, CA 91103, USA.ORCID 0009-0002-0496-2509
Aya AlhasanyDoheny Image Analysis Laboratory, Doheny Eye Institute, 150 N. Orange Grove Blvd., Pasadena, CA 91103, USA.
Ziyuan WangDoheny Image Analysis Laboratory, Doheny Eye Institute, 150 N. Orange Grove Blvd., Pasadena, CA 91103, USA.
Xiaomeng WuAnalytical Biochemistry Core Laboratory, Huntington Medical Research Institute, 686 S. Fair Oaks Avenue, Pasadena, CA 91105, USA.
Natalie AstraeaAnalytical Biochemistry Core Laboratory, Huntington Medical Research Institute, 686 S. Fair Oaks Avenue, Pasadena, CA 91105, USA.ORCID 0009-0009-6623-9763
Fei JiangDepartment of Epidemiology and Biostatistics, University of California, San Francisco, 50 16th Street, #2538, San Francisco, CA 94143, USA.
Zhihong Jewel HuDoheny Image Analysis Laboratory, Doheny Eye Institute, 150 N. Orange Grove Blvd., Pasadena, CA 91103, USA.ORCID 0000-0001-8307-0298
Jane W ChanDepartment of Ophthalmology, University of California, Los Angeles, 100 Stein Plaza Driveway, Los Angeles, CA 90095, USA.ORCID 0000-0002-7120-521X

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
Statistical tensor regression models for intracranial aneurysm growth predictionR01NS132766 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI fei jiang · 2024 to 2026
$1.6M
Development of Dynamic Resting State Functional Connectivity Machine Learning Framework for DementiaK25AG071840 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI fei jiang · 2022 to 2026
$701k
NIA NIH HHS K25 AG071840NIH HHS UL1 TR001872NINDS NIH HHS R01 NS132766
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

choroidinner retinanon-contactnon-invasiveouter retinaphotoreceptor inner segment thinningplasma Aβ42/40 ratioplasma glial fibrillary acidic proteinplasma neurofilament light chainplasma p-tau181plasma p-tau217pre-Alzheimer’s diseasesurrogate markers

Identifiers

PMID41517524
PMCPMC12786561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.