Evidence map›Paper›PMID 41517335›Full record

ArticleJournal of clinical medicine2025

Association of Mitochondrial DNA Haplogroups with Pediatric Systemic Lupus Erythematosus Disease Activity, Damage Scores, and Lupus Nephritis.

Viraat Udar, Shari R Atilano, Alexis V Stephens, Ryan Yu-Sheng Chang, Nicholas J Jackson, Steven Y Chang, Marilyn Chwa, Deborah McCurdy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Viraat UdarGenomeadvisors Inc., La Mirada, CA 90638, USA.ORCID 0000-0002-4345-4577
Shari R AtilanoGavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-7729-7864
Alexis V StephensDepartment of Pediatric Rheumatology, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-5979-6838
Ryan Yu-Sheng ChangGavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USA.
Nicholas J JacksonDepartment of Medicine Statistics Core, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-9515-5050
Steven Y ChangGavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-7124-8324
Marilyn ChwaGavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USA.
Deborah McCurdyDepartment of Pediatric Rheumatology, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-8914-3523

Funding

National Center for Advancing Translational Science UL1TR001881United States Department of Defense W81XWH-19-1-067
6 · The paper itself

Abstract

Mitochondria, which have critical roles in energy metabolism and oxidative regulation, also have a role in immune regulation including T cell activation, NET formation, inflammation, and apoptosis. More than 50% of those with systemic lupus erythematosus (SLE) have lupus nephritis due to kidney damage from immune complex deposition. Disease severity is reported to be greater in certain lineages. Mitochondrial DNA (mtDNA) haplogroups, which reflect maternal lineages, may modulate immune balance and disease outcomes in SLE.

Indexed as

lupus nephritismitochondriamitochondrial (mt) DNA haplogrouppediatric SLE (pSLE)systemic lupus erythematosus Disease Activity Index (SLEDAI-2K)systemic lupus erythematosus (SLE)Systemic Lupus Internal Collaborating Clinics (SLICC) Damage Index (SDI)

Identifiers

PMID41517335
PMCPMC12786546

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.