Mechanical Power and Driving Pressure: Mechanisms of Lung Injury, Markers of Pathophysiology, or Therapeutic Targets?

Gary Frank Nieman, Joaquin Araos, Joshua Satalin, Penny Andrews, Nader Habashi

Abstract read

In one paragraph

Article in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Targeting driving pressure in ARDS: refining the "When" and "How" after the STAMINA trial.Journal of thoracic disease · 2026
Article
Ventilator-induced lung injury: from mechanisms to integrated clinical management.Frontiers in medicine · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gary Frank NiemanDepartment of Surgery, Upstate Medical University, Syracuse, NY 13210, USA.ORCID 0000-0002-4541-4472

Joaquin AraosDepartment of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

Joshua SatalinDepartment of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

Penny AndrewsDepartment of Critical Care, R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD 21201, USA.

Nader HabashiDepartment of Critical Care, R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD 21201, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) causes heterogeneous injury, with normal, unstable, and edematous tissue distributed throughout the lung. Although positive pressure ventilation initially reduced ARDS-related mortality, it became clear that the ventilator can be a double-edged sword and, if set improperly, can worsen outcomes. This uneven pathology makes the lung vulnerable to secondary ventilator-induced lung injury (VILI). In 2000, evidence showed that lowering tidal volume (V

Indexed as

ARDSdriving pressureEELVlung recruitmentmechanical powerVILI

Identifiers

PMID41517329

DOI10.3390/jcm15010079

PMCPMC12786901

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.