Evidence map›Paper›PMID 41517320›Full record

ArticleJournal of clinical medicine2025

ChronoimmunoTOX: A Single-Institution Retrospective Study on How the Time of Administration Impacts Immune Checkpoint Inhibitor Efficacy and Toxicity in Melanoma.

Alessandro Nepote, Gilles Burghgraeve, Martino Pedrani, Anderson Junior Gomez Ramos, Isabella Saporita, Vito Spataro, Vittoria Espeli, Ricardo Pereira Mestre, Dario Sangiolo, Martina Imbimbo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alessandro NepoteIstituto Oncologico Svizzera Italiana, Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, 6500 Bellinzona, Switzerland.ORCID 0009-0009-9461-0478
Gilles BurghgraeveIstituto Oncologico Svizzera Italiana, Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, 6500 Bellinzona, Switzerland.
Martino PedraniIstituto Oncologico Svizzera Italiana, Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, 6500 Bellinzona, Switzerland.ORCID 0000-0002-8502-8226
Anderson Junior Gomez RamosIstituto Oncologico Svizzera Italiana, Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, 6500 Bellinzona, Switzerland.
Isabella SaporitaIstituto Oncologico Svizzera Italiana, Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, 6500 Bellinzona, Switzerland.
Vito SpataroIstituto Oncologico Svizzera Italiana, Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, 6500 Bellinzona, Switzerland.
Vittoria EspeliIstituto Oncologico Svizzera Italiana, Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, 6500 Bellinzona, Switzerland.
Ricardo Pereira MestreIstituto Oncologico Svizzera Italiana, Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, 6500 Bellinzona, Switzerland.ORCID 0000-0002-3123-3697
Dario SangioloDipartimento di Oncologia, Università di Torino, Regione Gonzole 10, 10043 Orbassano, Italy.ORCID 0000-0002-7163-7071
Martina ImbimboIstituto Oncologico Svizzera Italiana, Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, 6500 Bellinzona, Switzerland.ORCID 0000-0003-2521-7540
Cristina MangasIstituto Oncologico Svizzera Italiana, Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, 6500 Bellinzona, Switzerland.ORCID 0000-0002-7735-1349

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

anti CTLA-4Anti PD-1Chronoimmunotherapyimmune adverse eventsmelanoma

Identifiers

PMID41517320
PMCPMC12787149

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.