Evidence map›Paper›PMID 41516650›Full record

ArticleSensors (Basel, Switzerland)2025

Task-Dependent Cortical Oscillatory Dynamics in Functional Constipation.

Jianhua Li, Hui Yang, Mingwei Xu, Yiman Wu, Xiaokai Shou, Zhihui Huang, Yan Hao, Fangchao Wu, Weishuyi Ruan, Ying Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jianhua LiDepartment of Rehabilitation Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
Hui YangKey Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China.
Mingwei XuDepartment of Electrical & Computer Engineering, College of Engineering, University of Washington, Seattle, WA 98195, USA.
Yiman WuKey Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China.
Xiaokai ShouZhejiang Provincial Engineering Research Center of Rehabilitation Medicine Brain-Computer Interface Technology and Equipment, Hangzhou 311200, China.ORCID 0009-0006-6505-3949
Zhihui HuangDepartment of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
Yan HaoDepartment of Rehabilitation Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
Fangchao WuDepartment of Rehabilitation Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.ORCID 0000-0002-9648-557X
Weishuyi RuanDepartment of Rehabilitation Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
Ying ZhangDepartment of Rehabilitation Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
Zhengzhe CuiZhejiang Provincial Engineering Research Center of Rehabilitation Medicine Brain-Computer Interface Technology and Equipment, Hangzhou 311200, China.
Yina WeiInstitute for Brain and Intelligence, Fudan University, Shanghai 201203, China.

Funding

National Natural Science Foundation of China 32471148National Natural Science Foundation of China 62373326
6 · The paper itself

Abstract

Functional constipation (FC) is a common functional gastrointestinal disorder thought to arise from the brain-gut axis dysfunction, yet direct human neurophysiological evidence is lacking. We recorded high-density electroencephalography (EEG) data in 21 FC patients and 37 healthy controls across resting, cognitive, and defecation-related tasks. We observed that FC patients displayed a consistent, task-dependent signature compared with healthy controls. At the regional level, FC patients exhibited increased alpha during both resting and defecation-related tasks, reduced temporal gamma during defecation-related tasks, as well as elevated temporal theta during the cognitive task. At the global level, we found altered network properties, such as global efficiency in the delta and beta band networks during resting and defecation-related tasks. These findings establish a direct neurophysiological link between specific, condition-dependent perturbations in cortical rhythm activity and FC pathophysiology. Our work implicates the brain-gut axis in symptom generation and opens a path toward EEG-based biomarkers and targeted neuromodulatory therapies.

Indexed as

Cerebral CortexConstipationAdultDefecationElectroencephalographyFemaleHumansMaleMiddle Agedbrain–gut axiscortical oscillationselectroencephalography (EEG)functional constipation

Identifiers

PMID41516650
PMCPMC12788307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.