Haplotype GWAS in Colorectal Cancer Patients with a Family History of Gastric or Prostate Cancer.

David Kudrén, Linda Waage, Johanna Samola Winnberg, Mats Lindblad, Chunde Li, Annika Lindblom, Litika Vermani

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

David KudrénDepartment of Oncology, Södersjukhuset, 11833 Stockholm, Sweden.

Linda WaageDepartment of Clinical Science and Education, Karolinska Institutet, 11833 Stockholm, Sweden.

Johanna Samola WinnbergDivision of Surgery, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0002-3831-4801

Mats LindbladDivision of Surgery, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet, 17177 Stockholm, Sweden.

Chunde LiDepartment of Oncology, Södersjukhuset, 11833 Stockholm, Sweden.

Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0001-7675-7569

Litika VermaniDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 17177 Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous haplotype Genome Wide Association Studies (GWASs) have suggested several rare loci with a shared increased risk of colorectal, gastric, and prostate cancer. This study aimed to find out more about markers specifically addressing the shared risk of colorectal and gastric cancer, as well as the shared risk of colorectal and prostate cancer. One analysis used 426 colorectal cancer cases with gastric cancer, with no prostate cancer cases in their families, and another analysis used 324 colorectal cancer cases with prostate cancer but no gastric cancer among relatives. The computational program PLINK v1.07 was used for the analysis and for the calculation of corresponding ORs, standard errors, and 95% confidence intervals (CI). The study found support for the loci from previous studies and many new loci with a shared risk of colorectal cancer and gastric cancer. There were no significant loci from the second analysis for a shared risk of colorectal and prostate cancer. Altogether, more than 100 new loci with a shared risk of colorectal cancer and gastric cancer were suggested. A shared risk of colorectal and prostate cancer at some loci could not be ruled out. Haplotype GWAS has again demonstrated its ability to find rare risk loci mostly associated with coding genes.

Indexed as

Colorectal NeoplasmsGenome-Wide Association StudyHaplotypesProstatic NeoplasmsStomach NeoplasmsGenetic Predisposition to DiseaseHumansMalePolymorphism, Single Nucleotidecancer riskcolorectal cancerCRC syndromefamilialgastric cancergeneticGWAShaplotypepredispositionprostate cancer

Identifiers

PMID41516419

DOI10.3390/ijms27010547

PMCPMC12786866

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.