Evidence map›Paper›PMID 41516414›Full record

ArticleInternational journal of molecular sciences2026

Dicer Deletion in the Ear Can Cut Most Neurons and Their Innervation of Hair Cells to Project to the Ear and the Brainstem.

Ebenezer N Yamoah, Gabriela Pavlinkova, Jeong Han Lee, Jennifer Kersigo, Marsha L Pierce, Bernd Fritzsch

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ebenezer N YamoahDepartment of Translational Neurosciences, College of Medicine, University of Arizona, Phoenix, AZ 85004, USA.ORCID 0000-0002-9797-085X
Gabriela PavlinkovaInstitute of Biotechnology of the Czech Academy of Sciences, 25250 Vestec, Czech Republic.ORCID 0000-0002-5689-6577
Jeong Han LeeDepartment of Translational Neurosciences, College of Medicine, University of Arizona, Phoenix, AZ 85004, USA.
Jennifer KersigoDepartment of Pathology, University of Iowa Health Care, Iowa City, IA 52246, USA.
Marsha L PierceDepartment of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, IL 60515, USA.ORCID 0000-0002-7265-0104
Bernd FritzschDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-4882-8398

Funding

Structural Analyses CoreP01AG051443 · NIA · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2016 to 2025
$15.5M
Inner ear ion channels in healthy and diseased conditionsR01DC016099 · NIDCD · UNIVERSITY OF NEVADA RENO · PI EBENEZER N YAMOAH · 2017 to 2026
$4.7M
Mechanisms of Growth Factor Responsiveness in the Aging Auditory SystemR01AG060504 · NIA · UNIVERSITY OF NEVADA RENO · PI FRITZSCH, BERND, YAMOAH, EBENEZER N · 2018 to 2022
$2.5M
NIA NIH HHS AG051443NIA NIH HHS AG060504NIA NIH HHS P01 AG051443NIA NIH HHS R01 AG060504NIDCD NIH HHS R01 DC016099
6 · The paper itself

Abstract

Dicer is crucial for the generation of microRNAs (miRNAs), which are essential for regulating gene expression and keeping neuronal health. Dicer's conditional deletion cuts all spiral ganglion neurons but spares a small fraction of vestibular ganglion neurons, innervating the utricle and part of the saccule. Hair cells develop in the utricle, saccule, posterior crista, and the cochlea in

Indexed as

Brain StemDEAD-box RNA HelicasesHair Cells, AuditoryNeuronsRibonuclease IIIAnimalsGene DeletionMiceMicroRNAsSpiral GanglionDEAD-box RNA HelicasesDicer1 protein, mouseMicroRNAsRibonuclease IIIcochlear neuronsdevelopmentDicerhair cellsmiRNAneurogenesisprojectionsvestibular neuronsvestibular nuclei

Identifiers

PMID41516414
PMCPMC12787206

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.