Evidence map›Paper›PMID 41516410›Full record

ArticleInternational journal of molecular sciences2026

Endothelin-2 and Its Association with Uric Acid Levels and Systemic Inflammation: Relevance to Chronic Kidney Disease Progression.

Alexander Bozhidarov Blazhev, Krasimir Kostov, Borislav Ivanov Ignatov, Tsvetelina Eftimova, Tatyana Nedkova Simeonova, Svetla Ognyanova Blazheva

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander Bozhidarov BlazhevDepartment of Biology, Medical University-Pleven, 1 Kliment Ohridski Str., 5800 Pleven, Bulgaria.ORCID 0000-0003-0092-9488
Krasimir KostovDepartment of Physiology and Pathophysiology, Medical University-Pleven, 1 Kliment Ohridski Str., 5800 Pleven, Bulgaria.ORCID 0000-0003-2464-353X
Borislav Ivanov IgnatovDepartment of Physiology and Pathophysiology, Medical University-Pleven, 1 Kliment Ohridski Str., 5800 Pleven, Bulgaria.ORCID 0000-0002-0325-6162
Tsvetelina EftimovaHemodialysis Unit, St. Marina Hospital, 5800 Pleven, Bulgaria.
Tatyana Nedkova SimeonovaDepartment of Physiology and Pathophysiology, Medical University-Pleven, 1 Kliment Ohridski Str., 5800 Pleven, Bulgaria.ORCID 0000-0002-2307-1229
Svetla Ognyanova BlazhevaDepartment of Clinical Laboratory, Allergology and Clinical Immunology, Medical University-Pleven, 5800 Pleven, Bulgaria.ORCID 0000-0001-6870-941X

Funding

Bulgarian Ministry of Education and Science National Program "Young Scientists and Postdoctoral Students - 2"
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is associated with chronic inflammation and metabolic dysregulation. While endothelin-1 (ET-1) has been extensively studied, the role of endothelin-2 (ET-2) in CKD remains poorly understood. This cross-sectional study included 76 participants, 12 healthy controls and 64 CKD patients, stratified into three groups based on estimated glomerular filtration rate (eGFR): Group 1 (eGFR ≥ 90 mL/min/1.73 m

Indexed as

Endothelin-2InflammationRenal Insufficiency, ChronicUric AcidAdultAgedBiomarkersCase-Control StudiesCross-Sectional StudiesDisease ProgressionEndothelin-1FemaleGlomerular Filtration RateHumansInterleukin-6MaleBiomarkersEndothelin-1Endothelin-2Interleukin-6Uric Acidchronic kidney diseaseendothelin-1endothelin-2endothelin-3systemic inflammationuric acid

Identifiers

PMID41516410
PMCPMC12787035

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.