Biosynthesis of UV-Absorbing Mycosporine-like Amino Acids and Transcriptomic Profiling of Differential Gene Expression in Green Microalga Under Abiotic Stresses.

Georgia Tsintzou, Evmorfia Bataka, Georgia Tagkalaki, Sofoklis Keisaris, Nikolaos Tsiropoulos, Nikolaos Labrou, Panagiotis Madesis

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PubMed Full text at PMC Publisher

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Mycosporine-like Amino Acids Biosynthesis inMarine drugs · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Georgia TsintzouLaboratory of Molecular Biology of Plants, Department of Agriculture Crop Production and Rural Environment, School of Agricultural Sciences, University of Thessaly, 38446 Volos, Greece.ORCID 0009-0007-0204-2561

Evmorfia BatakaLaboratory of Biometry, Department of Agriculture Crop Production and Rural Environment, School of Agricultural Sciences, University of Thessaly, 38446 Volos, Greece.ORCID 0000-0003-1631-1949

Georgia TagkalakiFresh Formula Private Limited Cosmetics Manufacturing Company, 1st km Lavriou Ave Koropiou-Markopoulou, 19400 Koropi, Greece.

Sofoklis KeisarisInstitute of Applied Biosciences, Centre for Research and Technology, 57001 Thessaloniki, Greece.ORCID 0000-0002-4833-4726

Nikolaos TsiropoulosLaboratory of Analytical Chemistry and Agricultural Pharmacology, Department of Agriculture Crop Production and Rural Environment, School of Agricultural Sciences, University of Thessaly, 38446 Volos, Greece.ORCID 0000-0002-0688-4017

Nikolaos LabrouLaboratory of Enzyme Technology, Department of Biotechnology, School of Food, Biotechnology and Development, Agricultural University of Athens, 11855 Athens, Greece.ORCID 0000-0003-1925-9867

Panagiotis MadesisLaboratory of Molecular Biology of Plants, Department of Agriculture Crop Production and Rural Environment, School of Agricultural Sciences, University of Thessaly, 38446 Volos, Greece.ORCID 0000-0003-1447-3514

Funding

Marie Curie Rise projects 101086437University of Thessaly Innovation, Technology Transfer Unit and Entrepreneurship Center "One Planet Thessaly

6 · The paper itself

Abstract

Microalgae display remarkable resilience to harsh environments, partly through the biosynthesis of diverse secondary metabolites. Cyanobacteria and red algae are well known to produce mycosporine-like amino acids (MAAs)-low-molecular-weight, water-soluble UV-absorbing compounds with anti-inflammatory, anticancer, and antimicrobial activities. By contrast, green microalgae typically lack detectable MAAs under standard conditions, and their responses under abiotic stress remain poorly characterized. Here, we investigated the freshwater green microalga

Indexed as

Amino AcidsChlorophytaMicroalgaeStress, PhysiologicalTranscriptomeGene Expression ProfilingSalinityUltraviolet RaysAmino Acidsabiotic stressDEGsheatHPLCJaagichlorella luteoviridisMAAsmicroalgaesalinity SPFtranscriptomic analysisUV

Identifiers

PMID41516409

DOI10.3390/ijms27010537

PMCPMC12786583

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.