ArticleInternational journal of molecular sciences2026
Prolonged QT Interval in HIV-1 Infected Humanized Mice Treated Chronically with Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine.
Ali Namvaran, Julian V Garcia, Mahendran Ramasamy, Kayla Nguyen, Farzaneh Tavakkoli Ghazani, Bryan T Hackfort, Prasanta K Dash, Reagan E Fisher, Benson Edagwa, Santhi Gorantla and 1 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Ali NamvaranDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.ORCID 0000-0002-6490-2463 Julian V GarciaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.ORCID 0009-0003-6858-1788 Mahendran RamasamyDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
Kayla NguyenDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.ORCID 0000-0003-1536-4379 Farzaneh Tavakkoli GhazaniDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
Bryan T HackfortCellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
Prasanta K DashDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
Reagan E FisherDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.ORCID 0009-0002-8276-4620 Benson EdagwaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
Santhi GorantlaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
Keshore R BidaseeDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.ORCID 0000-0003-4165-8362 Funding
NIH HHS 1R01HL164306-03NIH HHS 1R56HL151602-02
6 · The paper itselfAbstract
The REPRIEVE Trial recently reported high rates of sudden cardiac death (SCD) middle-aged people living with HIV-1 infection (PWH) using the WHO/NIH-recommended two nucleoside reverse transcriptase inhibitors (NRTIs)/one integrase strand inhibitor (INSTI) regimen to manage HIV-1 viremia. To date, clinically relevant animal models to delineate underlying causes for this remain limited. Here, we assessed if HIV-1-infected NOD.Cg-
Indexed as
Anti-HIV AgentsEmtricitabineHeterocyclic CompoundsHIV-1HIV InfectionsLong QT SyndromeTenofovirAnimalsDisease Models, AnimalDolutegravirElectrocardiographyHumansMiceMice, Inbred NODOxazinesPiperazinesAnti-HIV AgentsDolutegravirEmtricitabineHeterocyclic CompoundsOxazinesPiperazinesPyridonesTenofovirantiretroviral therapyarrhythmiaelectrocardiographyHIV-1humanized miceQT intervalsudden cardiac death
Identifiers
PMID41516391
PMCPMC12786462
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