Geraniin Mitigates Neuropathic Pain Through Antioxidant, Anti-Inflammatory, and Nitric Oxide Modulation in a Rat Model of Chronic Constriction Injury.

Chih-Chuan Yang, Mao-Hsien Wang, Yi-Wen Lin, Chih-Hsiang Fang, Yu-Chuan Lin, Kuo-Chi Chang, Cheng-Chia Tsai

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chih-Chuan YangDepartment of Neurosurgery, Mackay Memorial Hospital, Taipei 10449, Taiwan.

Mao-Hsien WangDepartment of Anesthesia, En Chu Kon Hospital, New Taipei City 23702, Taiwan.

Yi-Wen LinInstitute of Biomedical Engineering, National Taiwan University, Taipei 10051, Taiwan.

Chih-Hsiang FangInstitute of Biomedical Engineering, National Taiwan University, Taipei 10051, Taiwan.ORCID 0000-0002-7797-6584

Yu-Chuan LinDepartment of Chinese Medicine, China Medical University Hospital, Taipei 114, Taiwan.

Kuo-Chi ChangNational Applied Research Laboratories, Institute of Taiwan Instrument Research, Hsinchu 300092, Taiwan.

Cheng-Chia TsaiDepartment of Neurosurgery, Mackay Memorial Hospital, Taipei 10449, Taiwan.

Funding

Mackay Memorial Hospital MMH-111-78 and 120

6 · The paper itself

Abstract

Neuropathic pain (NPP) remains therapeutically challenging, with oxidative/nitrosative stress and neuroinflammation-amplified by nitric oxide (NO)-as key drivers. This study investigated geraniin (GRN), a naturally occurring hydrolyzable ellagitannin widely distributed in various plant species, including

Indexed as

Anti-Inflammatory AgentsAntioxidantsGlucosidesHydrolyzable TanninsNeuralgiaNitric OxideAnimalsDisease Models, AnimalMaleOxidative StressRatsRats, WistarSciatic NerveAnti-Inflammatory AgentsAntioxidantsGeraniinGlucosidesHydrolyzable TanninsNitric Oxidechronic constriction injurygeraniininflammationneuropathic painnitric oxide

Identifiers

PMID41516382

DOI10.3390/ijms27010507

PMCPMC12787225

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.