Evidence map›Paper›PMID 41516355›Full record

ReviewInternational journal of molecular sciences2026

Human Leukocyte Antigen (

Alexia Onaciu, Alina Grama, Ștefan Agoșton, Alexandra Mititelu, Bianca Mariş, Horia Ştefănescu, Tudor Lucian Pop

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexia OnaciuFaculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Alina Grama2nd Pediatric Discipline, Department of Mother and Child, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Ștefan AgoștonFaculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Alexandra Mititelu2nd Pediatric Discipline, Department of Mother and Child, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Bianca Mariş2nd Pediatric Discipline, Department of Mother and Child, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Horia Ştefănescu"Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology, 400162 Cluj-Napoca, Romania.ORCID 0000-0002-4034-5471
Tudor Lucian Pop2nd Pediatric Discipline, Department of Mother and Child, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0002-4931-1219

Funding

Iuliu Hațieganu University of Medicine and Pharmacy 32152/14/16.12.2024
6 · The paper itself

Abstract

Drug-induced liver injury (DILI) remains one of the most challenging adverse drug reactions in clinical practice, particularly in its idiosyncratic form, which is not dose-dependent and is largely driven by host-specific immune and genetic factors. Recent genomic studies have revealed strong associations between certain human leukocyte antigen (

Indexed as

Chemical and Drug Induced Liver InjuryHLA AntigensAllelesAmoxicillin-Potassium Clavulanate CombinationFloxacillinGenetic Predisposition to DiseaseHLA-B AntigensHLA-DRB1 ChainsHumansMinocyclinePolymorphism, GeneticAmoxicillin-Potassium Clavulanate CombinationFloxacillinHLA AntigensHLA-B*57:01 antigenHLA-B AntigensHLA-DRB1 ChainsMinocyclineadaptive immune responsedrug-induced liver injuryHLA polymorphismsidiosyncratic drug reactions

Identifiers

PMID41516355
PMCPMC12787173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.