Evidence map›Paper›PMID 41516311›Full record

ArticleInternational journal of molecular sciences2025

Disruption of the Placenta-Brain Axis in Transgenic Mice Lacking Serotonin Transporter (SERT) in Trophoblast Cells.

David T Ellenberger, Zhen Lyu, Rosalind T B Herrington, Jessica A Kinkade, Gustavo W Leone, Ji Ying Sze, Nathan J Bivens, R Frank Baker, R Michael Roberts, Trupti Joshi and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

David T EllenbergerDepartment of Pathobiology and Integrative Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA.
Zhen LyuChristopher S. Bond Life Science Center, University of Missouri, Columbia, MO 65211, USA.
Rosalind T B HerringtonDepartment of Pathobiology and Integrative Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA.
Jessica A KinkadeVeterinary Diagnostic Laboratory, University of Missouri, Columbia, MO 65201, USA.
Gustavo W LeoneDepartment of Pathology & Laboratory Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Ji Ying SzeDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Nathan J BivensGenomics Technology Core Facility, University of Missouri, Columbia, MO 65211, USA.
R Frank BakerDepartment of Advanced Light Microscopy Core, Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0002-2392-6338
R Michael RobertsDepartment of Animal Sciences, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0002-0008-6559
Trupti JoshiChristopher S. Bond Life Science Center, University of Missouri, Columbia, MO 65211, USA.
Cheryl S RosenfeldDepartment of Pathobiology and Integrative Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0002-4137-3933

Funding

Characterizing the Placenta-Brain Axis in Transgenic Mice Lacking Serotonin Transporter (SERT) in Trophoblast CellsR03HD114968 · NICHD · UNIVERSITY OF MISSOURI-COLUMBIA · PI ROSENFELD, CHERYL SUSAN · 2025 to 2025
$157k
Eunice Kennedy Shriver National Institute of Child Health and Human Development 1R03HD114968-01A1Missouri Department of Health and Senior Services AOC23380006NICHD NIH HHS R03 HD114968
6 · The paper itself

Abstract

Serotonin reuptake inhibitors (SSRIs) are commonly prescribed to pregnant women experiencing depression. Such drugs, however, might adversely affect placenta and fetal brain development. Parietal trophoblast giant cells (pTGCs) in the mouse placenta are postulated to internalize maternal serotonin (5-HT) via transport through SERT, encoded by

Indexed as

BrainPlacentaSerotonin Plasma Membrane Transport ProteinsTrophoblastsAnimalsFemaleMaleMiceMice, KnockoutMice, TransgenicPregnancySerotoninSerotoninSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mousefetusneural developmentplacentaselective serotonin reuptake inhibitorstrophoblast giant cells

Identifiers

PMID41516311
PMCPMC12787258

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.