Evidence map›Paper›PMID 41516310›Full record

ReviewInternational journal of molecular sciences2025

PAK1 (p21-Activated Kinase 1) and Its Role in Neurodevelopmental Disorders-New Case Report and a Comprehensive Review.

Natasza Blek, Mikołaj Pielas, Volodymyr Kharytonov, Karolina Rutkowska, Joanna Rusecka, Sławomir Lewicki, Rafał Płoski, Piotr Zwoliński

Abstract readCase ReportsReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natasza BlekInstitute of Clinical Sciences, Maria Sklodowska-Curie Medical Academy in Warsaw, Pl. Żelaznej Bramy 10, 00-136 Warsaw, Poland.ORCID 0000-0002-3213-7330
Mikołaj PielasNeurosphera Epilepsy, Neurology and Psychiatry Centre, 02-829 Warsaw, Poland.ORCID 0009-0008-0094-2934
Volodymyr KharytonovNeurosphera Epilepsy, Neurology and Psychiatry Centre, 02-829 Warsaw, Poland.ORCID 0000-0002-9875-7209
Karolina RutkowskaDepartment of Medical Genetics, Medical University of Warsaw, 02-106 Warsaw, Poland.ORCID 0000-0001-6688-2593
Joanna RuseckaInstitute of Outcomes Research, Maria Sklodowska-Curie Medical Academy in Warsaw, Pl. Żelaznej Bramy 10, 00-136 Warsaw, Poland.ORCID 0000-0002-6936-9645
Sławomir LewickiInstitute of Outcomes Research, Maria Sklodowska-Curie Medical Academy in Warsaw, Pl. Żelaznej Bramy 10, 00-136 Warsaw, Poland.ORCID 0000-0002-0539-0680
Rafał PłoskiDepartment of Medical Genetics, Medical University of Warsaw, 02-106 Warsaw, Poland.ORCID 0000-0001-6286-5526
Piotr ZwolińskiNeurosphera Epilepsy, Neurology and Psychiatry Centre, 02-829 Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic variants in the

Indexed as

Neurodevelopmental Disordersp21-Activated KinasesBase SequenceChild, PreschoolFemaleGenetic Association StudiesHumansIntellectual Disabilityp21-Activated KinasesPAK1 protein, humande novo variantgenotype-phenotype correlationneurodevelopmental disorderPAK1

Identifiers

PMID41516310
PMCPMC12787292

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.