Evidence map›Paper›PMID 41516305›Full record

ArticleInternational journal of molecular sciences2025

HuR Knockdown in MLO-Y4 Osteocyte-like Cells Elevates OPG Expression and Suppresses Osteoclastogenesis In Vitro.

Ziqiu Fan, Hideki Kitaura, Aseel Marahleh, Abdulrahman Mousa, Fumitoshi Ohori, Alexandru Craevschi, Sherif Rashad, Hiroyasu Kanetaka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ziqiu FanOrthodontics and Dentofacial Orthopedics Department, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Miyagi, Japan.ORCID 0009-0009-8940-4979
Hideki KitauraOrthodontics and Dentofacial Orthopedics Department, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Miyagi, Japan.ORCID 0000-0003-3249-4247
Aseel MarahlehOrthodontics and Dentofacial Orthopedics Department, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Miyagi, Japan.ORCID 0000-0002-4324-3155
Abdulrahman MousaDepartment of Neurosurgical Engineering, Graduate School of Biomedical Engineering, Tohoku University, Sendai 980-8575, Miyagi, Japan.ORCID 0009-0004-2740-0183
Fumitoshi OhoriOrthodontics and Dentofacial Orthopedics Department, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Miyagi, Japan.
Alexandru CraevschiFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai 980-8578, Miyagi, Japan.
Sherif RashadDepartment of Neurosurgical Engineering, Graduate School of Biomedical Engineering, Tohoku University, Sendai 980-8575, Miyagi, Japan.ORCID 0000-0002-4511-6360
Hiroyasu KanetakaOrthodontics and Dentofacial Orthopedics Department, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Miyagi, Japan.

Funding

Japan Society for the Promotion of Science 25K02830Japan Society for the Promotion of Science 25K20447JST SPRING JPMJSP2114
6 · The paper itself

Abstract

Bone remodeling is maintained through the coordinated actions of osteoblasts, osteoclasts, and osteocytes, among which osteocytes serve as major regulators of osteoclast-mediated bone resorption through the receptor activator of the nuclear factor-κB ligand (RANKL)-osteoprotegerin (OPG) signaling axis. While molecular signals regulating osteocytic RANKL-OPG expression are fairly understood, how post-transcriptional mechanisms impact osteocyte function remains poorly defined. HuR (human antigen R) encoded by

Indexed as

ELAV-Like Protein 1OsteocytesOsteogenesisOsteoprotegerinAnimalsCell DifferentiationCell LineGene Expression RegulationGene Knockdown TechniquesMiceOsteoclastsRANK LigandRNA, MessengerRNA, Small InterferingElavl1 protein, mouseELAV-Like Protein 1OsteoprotegerinRANK LigandRNA, MessengerRNA, Small InterferingTnfrsf11b protein, mouseHuROPGosteoclastogenesisosteocyteRANKLRNA stability

Identifiers

PMID41516305
PMCPMC12786973

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.