Evidence map›Paper›PMID 41516289›Full record

ArticleInternational journal of molecular sciences2025

Establishment of Autoreactive CD4

Shuhei Mashimo, Michitsune Arita, Taku Kuwabara, Taku Naito, Sakurako Takizawa, Akiko Inoue, Akira Ishiko, Motonari Kondo, Yuriko Tanaka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuhei MashimoDepartment of Molecular Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan.
Michitsune AritaDepartment of Molecular Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan.
Taku KuwabaraDepartment of Molecular Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan.ORCID 0000-0001-5985-8245
Taku NaitoDepartment of Molecular Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan.
Sakurako TakizawaDepartment of Molecular Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan.
Akiko InoueDepartment of Otorhinolaryngology, Toho University Omori Medical Center, Tokyo 143-8541, Japan.ORCID 0000-0001-5097-7811
Akira IshikoDepartment of Dermatology, Toho University Omori Medical Center, Tokyo 143-8541, Japan.ORCID 0000-0002-1163-870X
Motonari KondoDepartment of Molecular Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan.ORCID 0000-0002-1565-8804
Yuriko TanakaDepartment of Molecular Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan.ORCID 0000-0002-9278-7677

Funding

Ministry of Education, Culture, Sports, Science and Technology 17K08892Ministry of Education, Culture, Sports, Science and Technology 18K07075Ministry of Education, Culture, Sports, Science and Technology 19K23871Ministry of Education, Culture, Sports, Science and Technology 20K18296Ministry of Education, Culture, Sports, Science and Technology 22K07030Ministry of Education, Culture, Sports, Science and Technology 23K15874Ministry of Education, Culture, Sports, Science and Technology 24390121Ministry of Education, Culture, Sports, Science and Technology 24K10264Ministry of Education, Culture, Sports, Science and Technology 24K10276Ministry of Education, Culture, Sports, Science and Technology 25460600Ministry of Education, Culture, Sports, Science and Technology 26670240
6 · The paper itself

Abstract

Sjögren's disease (SjD), which is also known as Sjögren's syndrome (SS), is a chronic autoimmune disease characterized by dysfunction of exocrine glands, such as the salivary and lacrimal glands, resulting in xerostomia (dry mouth) and keratoconjunctivitis sicca (dry eyes). Mice in which the SATB1 gene is conditionally deleted in hematopoietic cells (SATB1cKO mice) develop SS as early as 4 weeks of age; however, the etiology of the disease remains to be elucidated. Here, we found that the frequency of abnormally appearing CD4

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesMatrix Attachment Region Binding ProteinsSjogren's SyndromeAnimalsDisease Models, AnimalMiceMice, KnockoutSalivary GlandsMatrix Attachment Region Binding ProteinsSatb1 protein, mouseautoimmunitycomplementarity determining region 3Sjögren’s diseaseT cell hybridomaT cell receptor

Identifiers

PMID41516289
PMCPMC12787129

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.