α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue via Coordinated NRF2-Mediated Antioxidant Defense and AKT/GS-Driven Hepatic Glycogen Supercompensation in Mice.

Lifang Zheng, Yinian Wang, Zirui Xiao, Zhijian Rao, Rengfei Shi

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

The journey of bioactive peptides in vivo: cutting-edge advances in absorption, transport, and bioavailability.Bioprocess and biosystems engineering · 2026
Review
Nutritional Interventions and Acupuncture-Based Strategies for Exercise-Induced Fatigue and Recovery: Mechanisms and Integrative Perspectives.Food science & nutrition · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lifang ZhengDepartment of Kinesiology, College of Physical Education, Shanghai University, Shanghai 200444, China.

Yinian WangDepartment of Kinesiology, College of Physical Education, Shanghai Normal University, Shanghai 200234, China.

Zirui XiaoDepartment of Kinesiology, College of Physical Education, Shanghai Normal University, Shanghai 200234, China.

Zhijian RaoDepartment of Kinesiology, College of Physical Education, Shanghai Normal University, Shanghai 200234, China.

Rengfei ShiDepartment of Kinesiology, College of Exercise and Health, Shanghai University of Sport, Shanghai 200238, China.ORCID 0000-0002-8310-6526

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise-induced fatigue involves oxidative stress and metabolic dysregulation. While the anti-aging protein α-Klotho regulates metabolism and oxidative stress, its role in exercise fatigue is unexplored. This study investigated whether α-Klotho supplementation mitigates cumulative exercise-induced fatigue and elucidated the underlying tissue-specific mechanisms. Male C57BL/6J mice were divided into three groups (

Indexed as

AntioxidantsFatigueGlucuronidaseLiver GlycogenNF-E2-Related Factor 2Physical Conditioning, AnimalProto-Oncogene Proteins c-aktAnimalsDietary SupplementsGlycogenKlotho ProteinsLiverMaleMiceMice, Inbred C57BLMuscle, SkeletalAntioxidantsGlucuronidaseGlycogenKlotho ProteinsLiver GlycogenNfe2l2 protein, mouseNF-E2-Related Factor 2Proto-Oncogene Proteins c-aktexercisefatigueglycogen synthesisNRF2 pathwayα-klotho

Identifiers

PMID41516284

DOI10.3390/ijms27010412

PMCPMC12785555

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.