Cross-Species Transcriptomic and Metabolomic Analysis Reveals Conserved and Divergent Fatty Acid Metabolic Regulatory Strategies During Mammalian Oocyte Maturation.

Mostafa Elashry, Yassin Kassim, Bingjie Hu, Hao Sheng, Guangjun Xu, Hagar Elashry, Kun Zhang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Plasma Lipidomics Identify Pathways Linked to Acute Lung Injury in a Porcine One-Lung Ventilation Surgery Model.International journal of molecular sciences · 2026
Article

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5 · Who and what money

Authors and funding

7 authors.

Mostafa ElashryKey Laboratory of Dairy Cow Genetic Improvement and Milk Quality Research of Zhejiang Province, College of Animal Sciences, Zhejiang University, Room 301 E Building, 866 Yuhangtang Rd., Hangzhou 310058, China.ORCID 0000-0003-3748-067X

Yassin KassimKey Laboratory of Dairy Cow Genetic Improvement and Milk Quality Research of Zhejiang Province, College of Animal Sciences, Zhejiang University, Room 301 E Building, 866 Yuhangtang Rd., Hangzhou 310058, China.ORCID 0009-0000-4025-8039

Bingjie HuKey Laboratory of Dairy Cow Genetic Improvement and Milk Quality Research of Zhejiang Province, College of Animal Sciences, Zhejiang University, Room 301 E Building, 866 Yuhangtang Rd., Hangzhou 310058, China.

Hao ShengKey Laboratory of Dairy Cow Genetic Improvement and Milk Quality Research of Zhejiang Province, College of Animal Sciences, Zhejiang University, Room 301 E Building, 866 Yuhangtang Rd., Hangzhou 310058, China.

Guangjun XuKey Laboratory of Dairy Cow Genetic Improvement and Milk Quality Research of Zhejiang Province, College of Animal Sciences, Zhejiang University, Room 301 E Building, 866 Yuhangtang Rd., Hangzhou 310058, China.

Hagar ElashryNutrition and Clinical Nutrition Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.ORCID 0009-0002-2112-2923

Kun ZhangKey Laboratory of Dairy Cow Genetic Improvement and Milk Quality Research of Zhejiang Province, College of Animal Sciences, Zhejiang University, Room 301 E Building, 866 Yuhangtang Rd., Hangzhou 310058, China.ORCID 0000-0002-2324-9381

Funding

"Pioneer" and "Leading Goose" R&D Program of Zhejiang 15 (2024C04033 to K.Z.) and the National Natural Science Foundation of China (32472902 to K.Z.). 2024C04033 to K.Z.; 32472902 to K.Z.

6 · The paper itself

Abstract

Mammalian oocyte maturation is a metabolically demanding process relying on lipid metabolism that supplies energy, structural substrates, and signaling mediators. However, a comprehensive cross-species understanding of the dynamic requirement for lipids during this process remains elusive, hindering the optimization of assisted reproductive technologies. Utilizing an integrated single-cell transcriptomic and targeted lipidomic approach, we mapped the metabolic landscape of bovine oocyte maturation. Our analysis uncovered a global transcriptional downregulation, with 3259 genes suppressed during the transition from the germinal vesicle (GV) to the metaphase II (MII) stage. This was particularly apparent in lipid catabolism pathways (e.g., for

Indexed as

Fatty AcidsMetabolomeMetabolomicsOocytesOogenesisTranscriptomeAnimalsCattleFemaleGene Expression ProfilingLipid MetabolismLipidomicsMultiomicsSpecies SpecificityFatty Acidslipidlipidomicsmeiosismetabolomicsoocytetranscriptomics

Identifiers

PMID41516270

DOI10.3390/ijms27010397

PMCPMC12785767

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.