Evidence map›Paper›PMID 41516261›Full record

ArticleInternational journal of molecular sciences2025

Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway.

Qian Zeng, Min-Lin Liao, Yu-Yang Luo, Shuang Li, Gao You, Chong-Mei Huang, Min-Hui Liu, Wei Liu, Si-Yuan Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qian ZengXiangya Nursing School, Central South University, 172 Tongzipo Road, Changsha 410013, China.
Min-Lin LiaoXiangya Nursing School, Central South University, 172 Tongzipo Road, Changsha 410013, China.
Yu-Yang LuoXiangya Nursing School, Central South University, 172 Tongzipo Road, Changsha 410013, China.
Shuang LiXiangya Nursing School, Central South University, 172 Tongzipo Road, Changsha 410013, China.
Gao YouXiangya Nursing School, Central South University, 172 Tongzipo Road, Changsha 410013, China.
Chong-Mei HuangSchool of Nursing, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750003, China.ORCID 0000-0001-6794-0724
Min-Hui LiuSchool of Nursing, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750003, China.
Wei LiuXiangya Nursing School, Central South University, 172 Tongzipo Road, Changsha 410013, China.ORCID 0000-0003-0948-7807
Si-Yuan TangSchool of Nursing, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750003, China.

Funding

Graduate Student Research and Innovation Program of Central South University 2024ZZTS0527Graduate Student Research and Innovation Program of Central South University 2025ZZTS0186National Natural Science Foundation of China 82100084National Natural Science Foundation of China 82170853Natural Science Foundation of Ningxia 2024AAC02044
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis is a chronic, progressive, interstitial lung disease for which specific and effective drug therapies are still lacking. Lathyrol is a diterpene compound with broad pharmacological activities that can be extracted from the traditional Chinese medicine

Indexed as

LanosterolPPAR gammaPulmonary FibrosisSignal TransductionSmad3 ProteinSmad ProteinsTransforming Growth Factor betaAnimalsBleomycinCell LineDisease Models, AnimalFibroblastsHumansMaleMiceMice, Inbred C57BLBleomycinLanosterolPPAR gammaSmad3 ProteinSmad ProteinsTransforming Growth Factor betalathyrolPPARγpulmonary fibrosisTGF-β/Smad signaling pathway

Identifiers

PMID41516261
PMCPMC12785948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.